Narcolepsy Flashcards
What did Schammel find
narcolepsy was onset after a stroke
What did Arri find
a tumour in the hypothalamus reduced hcrt
what did Dement find
mice who couldn’t make hurt suffered from narcolepsy
What did Nichino and Mingot find
genetic mutation in dogs affects Hcrt production
what is the concordance rate
30%
what did Sakura find
Hurt in brain promotes REM
What is a practical application
provgil drug activates hcrt
Why does this explanation have no causalty
not all narcolepsy sufferers have the HLA mutation
what is narcolepsy
attacks of sleep that affect the ability to regulate the sleep wake cycle
what is the neural explanation
damage to the hypothalamus
what is the hypocretin explanation
sufferers have 80% less Hcrt which regulates arousal and wakefulness
what is the genetic explanation
damage to chromosome 12 could be an issue as it usually regulates brain receptors and Hcrt production
what is the emotional explanation
excess happiness and humour can induce attacks
