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NAPLEX > NAPLEX ** > Flashcards

NAPLEX ** Flashcards

1
Q

epzicom

A

lamivudine and abacavir

both NRTIs

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2
Q

triumeq

A

lamivudine, abacavir, dolutegravir

a preferred option in treatment naive patients

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3
Q

Genvoya

A

cobicistat, elvitegravir, emtricitabine, tenofovir AF
strong 3A4 inhibitor
first line, single pill

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4
Q

elvitegravir considerations

A

do not administer with polyvalent cations

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5
Q

NRTIs

A 
cause DNA chain termination, blocking viral DNA synthesis by reverse transcriptase
entire class has a boxed warning for lactic acidosis
do not undergo transformation via CYP450
require renal dose adjustments, except for abacavir
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6
Q

truvada

A

emtricitabine + tenofovir disoproxil fumarate

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7
Q

Viread

A

tenofovir DF

NRTI

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8
Q

rilpivirine side effects

A

in complera

depression, mood changes, insomnia, suicidal idealation

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9
Q

HIV medication that can cause asymptomatic jaundice

A

Reyetaz (atazanavir) “bananavir”

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10
Q

protease inhibitor recommended in a preferred regimen for treatment-naive paitents

A

Darunavir

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11
Q

PEP duration

A

4 weeks

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12
Q

Isentress

A 
raltegravir
avoid polyvalent cations (give 2 hours before or 6 hours after)
400 BID or 1200 daily both appropriate
can give with food
can increase CPK
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13
Q

PrEP medications

A

truvada
(emtricitabine + TDF)
will require HIV testing q3months during PrEP

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14
Q

complera

A

emtricitabine + TDF + rilpivarine

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15
Q

prezista

A

darunavir
should always be given with boosting agent (ritonavir or cobicistat), has a sulfa moiety so should be used with caution in allergy, st johns wort can decrease levels, take with food, monitor lipids and glucose

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16
Q

Zidovudine

A

IV formulation used to prevent perinatal transmission during delivery

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17
Q

CCR5 testing required before starting

A

maraviroc

will only be effective in CCR5-tropic disease

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18
Q

PPIs are contraindicated with what HIV meds?

A

rilpivirine (Edurant) containing products

i.e. complera, edurant, odefsey

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19
Q

HIV medications to take with food

A

most PIs to decrease GI upset

i.e. edurant, prezista, reyataz

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20
Q

HIV meds that should be taken on an empty stomach at bedtime

A

sustiva (efavirenz) and atripla (efavirenz + emtricitabine + TDF)

21
Q

descovy

A

emtricitabine + TAF

22
Q

stribild in renal impairment

A

cobicistat increases Cr (without damaging kidneys), tenofovir causes nephrotoxicity
do not start if less than 70, d/c if less than 50
genvoya can be used until CrCl less than 30

23
Q

cobicistat use

A

3A4 inhibitor to boost levels

24
Q

stribild

A

elvitegravir + cobicistat + emtricitabine + TDF

25
Q

abacavir

A

Ziagen
risk of serious, possibly fatal hypersensitivty reaction
If HLA-B*5701 positive, do NOT give
abacavir + lamivudine is Epzicom

26
Q

symbicort ingredients

A

formoterol + budesonide

27
Q

airduo ingredients

A

fluticasone + salmeterol

28
Q

theophylline levels

A

peak at SS 5-15

29
Q

humulin n stable at room temp for

A

14 days

30
Q

leukocytosis vs leukopenia

A 
cytosis = high
penia = low
31
Q

digoxin level

A
  1. 5-0.9 for HF

0. 8-2 for AF

32
Q

max lifetime dose of bleomycin

A

400 units sue to risk of pulmonary toxicity

33
Q

chemo pulmonary fibrosis agents

A

carmustine, busulfan, bleomycin, and lomustine

34
Q

rituximab PG testing

A

CD20 positive to use

35
Q

rituximab can activate what?

A

Hep B

36
Q

max dose of vincristine

A

2 mg

37
Q

cetuximab PG testing *

A

EGFR

KRAS negative

38
Q

simvastatin and diltiazem

A

max simvastatin dose 10 mg due to 3A4

max simvastatin dose 20 mg with ranolazine

39
Q

niacin side effects

A

increased blood sugar, increased uric acid, flushing and/or itching

40
Q

niaspan administration

A

at bedtime after a low-fat snack

41
Q

lovaza side effects

A

burping, dyspepsia, taste perversions

42
Q

fenofibrate contraindications

A

severe liver disease, gallbladder disease

43
Q

odefsey

A

rilpivirine + emtricitabine + TAF

same as complera (TDF) but TAF

44
Q

tivicay

A

dolutegravir

INSTI

45
Q

fuzeon

A

enfuvirtide
SC inj
almost 100% experience inj site reactions

46
Q

drugs that can increase LDL

A

fenofibrate, geodon, dexamethasone, lovaza

47
Q

mipomersin contraindication

A

mod-severe hepatic impairment or hepatic disease

48
Q

myalept indication

A

leptin deficiency with congenital or acquired generalized lipodystrophy

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