NAPLEX ** Flashcards
epzicom
lamivudine and abacavir
both NRTIs
triumeq
lamivudine, abacavir, dolutegravir
a preferred option in treatment naive patients
Genvoya
cobicistat, elvitegravir, emtricitabine, tenofovir AF
strong 3A4 inhibitor
first line, single pill
elvitegravir considerations
do not administer with polyvalent cations
NRTIs
cause DNA chain termination, blocking viral DNA synthesis by reverse transcriptase entire class has a boxed warning for lactic acidosis do not undergo transformation via CYP450 require renal dose adjustments, except for abacavir
truvada
emtricitabine + tenofovir disoproxil fumarate
Viread
tenofovir DF
NRTI
rilpivirine side effects
in complera
depression, mood changes, insomnia, suicidal idealation
HIV medication that can cause asymptomatic jaundice
Reyetaz (atazanavir) “bananavir”
protease inhibitor recommended in a preferred regimen for treatment-naive paitents
Darunavir
PEP duration
4 weeks
Isentress
raltegravir avoid polyvalent cations (give 2 hours before or 6 hours after) 400 BID or 1200 daily both appropriate can give with food can increase CPK
PrEP medications
truvada
(emtricitabine + TDF)
will require HIV testing q3months during PrEP
complera
emtricitabine + TDF + rilpivarine
prezista
darunavir
should always be given with boosting agent (ritonavir or cobicistat), has a sulfa moiety so should be used with caution in allergy, st johns wort can decrease levels, take with food, monitor lipids and glucose
Zidovudine
IV formulation used to prevent perinatal transmission during delivery
CCR5 testing required before starting
maraviroc
will only be effective in CCR5-tropic disease
PPIs are contraindicated with what HIV meds?
rilpivirine (Edurant) containing products
i.e. complera, edurant, odefsey
HIV medications to take with food
most PIs to decrease GI upset
i.e. edurant, prezista, reyataz
HIV meds that should be taken on an empty stomach at bedtime
sustiva (efavirenz) and atripla (efavirenz + emtricitabine + TDF)
descovy
emtricitabine + TAF
stribild in renal impairment
cobicistat increases Cr (without damaging kidneys), tenofovir causes nephrotoxicity
do not start if less than 70, d/c if less than 50
genvoya can be used until CrCl less than 30
cobicistat use
3A4 inhibitor to boost levels
stribild
elvitegravir + cobicistat + emtricitabine + TDF
abacavir
Ziagen
risk of serious, possibly fatal hypersensitivty reaction
If HLA-B*5701 positive, do NOT give
abacavir + lamivudine is Epzicom
symbicort ingredients
formoterol + budesonide
airduo ingredients
fluticasone + salmeterol
theophylline levels
peak at SS 5-15
humulin n stable at room temp for
14 days
leukocytosis vs leukopenia
cytosis = high penia = low
digoxin level
- 5-0.9 for HF
0. 8-2 for AF
max lifetime dose of bleomycin
400 units sue to risk of pulmonary toxicity
chemo pulmonary fibrosis agents
carmustine, busulfan, bleomycin, and lomustine
rituximab PG testing
CD20 positive to use
rituximab can activate what?
Hep B
max dose of vincristine
2 mg
cetuximab PG testing *
EGFR
KRAS negative
simvastatin and diltiazem
max simvastatin dose 10 mg due to 3A4
max simvastatin dose 20 mg with ranolazine
niacin side effects
increased blood sugar, increased uric acid, flushing and/or itching
niaspan administration
at bedtime after a low-fat snack
lovaza side effects
burping, dyspepsia, taste perversions
fenofibrate contraindications
severe liver disease, gallbladder disease
odefsey
rilpivirine + emtricitabine + TAF
same as complera (TDF) but TAF
tivicay
dolutegravir
INSTI
fuzeon
enfuvirtide
SC inj
almost 100% experience inj site reactions
drugs that can increase LDL
fenofibrate, geodon, dexamethasone, lovaza
mipomersin contraindication
mod-severe hepatic impairment or hepatic disease
myalept indication
leptin deficiency with congenital or acquired generalized lipodystrophy
