NAPLEX Flashcards
Bumex
Bumetanide
*Sulfa allergy
*1mg Bumex = 40mg Lasix
Lasix
furosemide
- Protect IV from LIGHT
Maxzide
Diazide
triamterene/ hydrochlorothiazide
Zaroxolyn
metolazone
- thiazide-related that can be used in renal failure
Aldactone
spironolactone
- SE: gynecomastia; HF dose: 50mg QD
Lotensin
benazepril
Vasotec
enalapril
- only ACE that comes in IV form
Zestril
Prinivil
lisinopril
Zestoretic
lisinopril w/ HCTZ
Accupril
quinapril
Altace
ramipril
- only ACEI that comes in capsules
Avapro
irbesartan
Cozaar
losartan
Hyzaar
losartan w/ HCTZ
Diovan
valsartan
Benicar
olmesartan
Micardis
telmisartan
Normodyne
labetalol
- tk with food. safe in preggo
Bystolic
nebivolol
- ↑ nitric oxide (vasodilation)
Tenormin
atenolol
Coreg, Coreg CR
carvedilol
- tk with food
Inderal
propanolol
- tk with food
Lopressor
metoprolol tartrate
*IR - take with food
Toprol XL
metoprolol succinate
- can be split in half
- for HF, start at 12.5mg, ↑ to TD of 200mg/day
Zebeta
bisoprolol
Calan SR
Verelan
Verelan PM
verapamil
*PO/IV for ventricular rate control
*inhibitor/substrate of CYP3A4
Cardizem
Tiazac
Taztia XT
diltiazem
*PO/IV for ventricular rate control
*inhibitor/substrate of CYP3A4
Cardizem, Tiazac, Taztia XT
diltiazem
*PO/IV for ventricular rate control
*inhibitor/substrate of CYP3A4
Norvasc
amlodipine
*substrate of CYP3A4
*weak inhibitor of CYP3A4
Plendil
felodipine
*substrate of CYP3A4
*ER
*do not crush or chew
*QD
Procardia
Procardia XL
nifedipine
*substrate of CYP3A4
Catapres
Catapres TTS
Kapvay
clonidine
*1 patch q7d
Tenex
Intuniv
guanfacine
Tenex → ADHD
Apresoline
hydralazine
*safe in pregnancy
BiDil
Isosorbide dinitrate + hydralazine
*used for HF
Minipress
Prazosin
*short acting
*not for BPH
*only for HTN
[alpha 1-blocker]
Cardura
Cardura XL
doxazosin
*indicated for HTN and BPH
*titrate due to risk of orthostatic ↓BP
[alpha 1-blocker]
Hytrin [brand DSC]
terazosin
*indicated for HTN and BPH
*titrate due to risk of orthostatic ↓BP
[alpha 1-blocker]
Flomax
tamsulosin
*SULFA
*tk 30 min after same meal each day
[alpha 1-blocker]
Rapaflo
silodosin
*QD
*WITH FOOD
*Caps can be opened and sprinkled onto applesauce
[alpha 1-blocker]
Uroxatral
alfuzosin
*tk with same meal each day
[alpha 1-blocker]
Avodart
-dosing
dutasteride
*males: PO: 0.5mg QD alone or in combo with tamsulosin
[5 Alpha-reductase Inhibitor]
Proscar
Propecia
-dosing
finasteride
*proscar: 5mg for BPH
*propecia: 1mg for male pattern baldness
[5 Alpha-reductase Inhibitor]
Lotrel
amlodipine + benazepril
Ziac
bisoprolol + HCTZ
Ziac
bisoprolol + HCTZ
Ziac
bisoprolol + HCTZ
Tarka
verapamil + tandolapril
*with food
Prestalia
amlodipine + perindopril
Exforge
amlodipine + valsartan
Twynsta
amlodipine + telmisartan
Azor
amlodipine + olmesartan
Caduet
amlodipine + atorvastatin
Consensi
amlodipine + celecoxib
isosorbide mononitrate
-dosing
IR: 20mg BID with the 2 doses given 7 hours apart
Isosordil
-when to administer
isosorbide dinitrate
*dont administer around the clock to prevent tolerance; allow nitrate free interval ≥14h (IR) and ≥18h (SR)
*IR : BID : 8AM and 1PM
*TID: 8AM, 1PM, 6PM
Nitrostat
NitroBid
-storage
nitroglycerin
*IV must be in GLASS bottle
Ranexa
-indication
-CI
ranolazine
*indicated for chronic stable angina
*CI: hepatic impairment
Heparin
-dosage form
-monitoring parameters
-doses
*IV/SQ
*IV: monitor Hgb, Hct, platelet, aPTT, signs of bleeding
*Heparin lock flush is intended to maintain IV line open (NOT anticoagulant tx)
*1,2,10,100 units/mL
Lovenox
-monitoring
-dosing
-CI
-antidote
enoxaparin
*monitoring: platelet, hemoglobin , hematocrit, fecal occult blood, bleeding signs, anti-factor Xa levels (as appropriate), serum creatinine at baseline and during tx
*DVT prophylaxis in hip/knee replacement: 30mg SC q12h, start 12-24h post-op for 7-10d
40mg SC QD
CrCl <30: 30 mg SC QD
*DVT prophylaxis in abdominal surgery: 40mg SC QD start 2h pre op no more than 12 days
*DVT treatment: 1mg/kg SC q12h or 1.5mg/kg QD
CrCl <30: 1mg/kg SC QD
*MI/ unstable angina/ thrombolytic adjunct/ PIC: ID 30mg IV single bolus + 1 mg/kg SC q12h w/ aspirin
*CI: pork allergy
*antidote: protamine
Pradaxa
-drug class
-antidote
-storage
dabigatran
*direct thrombin inhibitor: inhibits factor IIa
*antidote: idarucizumab (Praxbind)
*KEEP IN ORIGINAL BOTTLE. Once opened - 4m
Praxbind
idarucizumab
Eliquis
-dosing
-antidote
apixaban
*DOSED BID
*antidote: Andexanet alfa (Andexxa) (IV)
Andexxa
Andexanet alfa
Xarelto
-dosing
-antidote
rivaroxaban
*DVT prophylaxis: Knee (12d) or hip (35d): 10mg QD
*Stroke prophylaxis in non-Valv Afib:
CrCl>50 : 20mg QD with PM meal
*DVT/PE tx: 15mg BID x 21d; then 20mg QD for 3m or +
*Antidote: andexanet alfa (Andexxa) (IV)
Jantoven
-monitor
-antidote
warfarin
*Monitor: INR, Hgb, Hit, hematocrit, bleeding signs
*CYP inhibitors will ↑ INR, CYP inducer ↓ INR
*Antidote: VitK (phytonadione) (Mephyton)
Mephyton
Phytonadione (Vitamin K)
Plavix
-dosing
-drug class
clopidogrel
*LD: 300mg → 75mg QD
*Prodrug: CYP2C19 inhibitor ↓ plavix
[ADP receptor P2Y12 inhibitor] irreversible
Efficient
-dosing
-drug class
prasugrel
*60mg LD →10mg QD
[ADP receptor P2Y12 inhibitor] irreversible
Brilinta
-LD/MD
-BBW
-drug class
ticagrelor
*LD: 180mg (2 x 90mg)
*MD: 90mg BID
*BBW: aspirin dose >100mg reduces effectiveness
[ADP receptor P2Y12 inhibitor] reversible
Aggrenox
dipyridamole + aspirin
*CI: salicylate allergy
Pacerone
Nexterone
Amiodarone
*DI with warfarin (↑INR)
*dont give sofosbuvir
Multaq
dronedarone
*with FOOD
*avoid grapefuit juice
*watch for liver failure and HF
Betapace
Betapace AF
Sotalol
Tikosyn
dofetilide
*PO
*do not use if CrCl <20
*CI w/ HCTZ, citalopram: QT prolongation
Lanoxin
Digitek
Digox
-antidote
digoxin
Antidote: Digifab
Statins Monitoring Parameters
*Lipid Panels
*LFT: at baseline
*Muscle aches: CPK: not routine: if muscle ache
Lipitor
-max dose
atorvastatin
*MAX 80mg
Crestor
-max dose
rosuvastatin
*MAX 40mg except Asians (ID: 5mg/ MAX: 20mg)
Crestor
rosuvastatin
Zocor
-max dose
simvastatin
*MAX 40mg
Vytorin
ezetimibe + simvastatin
Pravachol
-max dose
pravastatin
*least drug interactions
*MAX 80mg
Mevacor
-max dose
lovastatin
*IR with evening meal
*MAX 80mg
Lopid
gemfibrozil
*do not use with statin: ↑ myopathy
Tricor
Lipofen
Antara
Lofibra
fenofibrate
*Lipofen and Antara taken with food
Trilipix
Fibricor
fenofibric acid
Praluent
-dosing
-storage
-drug class
alirocumab
*SQ once q2w
*in the fridge
[PCSK9 inhibitor]
Repatha
-dosing
-storage
-drug class
evolcumab
*SQ 140mg q2w or 420mg qm
*in the fridge
[PCSK9 inhibitor]
Zetia
-dosing
ezetimibe
*10mg QD
Niacor
Niaspan
Niacin (Vitamin B3)
*with food
*tk ASA 325mg 30min before dose to reduce flushing
Lovaza
omega-3
*↑risk of bleeding with warfarin
Synthroid
Levoxyl
Levothyroid
levothyroxine
*T4
*must take on empty stomach
Cytomel
Triostat
liothyronine
*T3
*rapid absorption, rapid onset
PTU
propylthiouracil
*preferred in 1st trimester of pregnancy
*indicated for hyperthyroidism
Tapazole
methimazole
*preferred in 2nd and 3rd trimester of pregnancy
*indicated for hyperthyroidism
Androgel
Androderm
testosterone
*comes in gel and transdermal patches
*CIII
Estrace
Premarin
estradiol
*PO and vaginal cream
Provera
Depo-Provera
medroxyprogesterone
*PO
*Depo-Provera: IM/SQ: q3m
Proometrium
progesterone
*CI: PEANUT ALLERGY
CombiPatch
estradiol + norethindrone
*1 patch twice weekly
*REFRIGERATE
Proventil HFA
Ventolin HFA
ProAir HFA
RespiClick
albuterol
*Priming: Proair (3 sprays), Ventolin/Proventil (4 sprays)
*Re-priming if not used >14d
*RespiClick: Discard 13m after removal from foil pouch
*for acute asthma
Xopenex
levalbuterol
*Neb: once foiled is opened, good for 2w. out of foil, 1w
*HFA: prime 4 sprays & after 3d of non=use
*for acute asthma
Flovent HFA
Flovent Diskus
Arnuity Ellipta
fluticasone
*QD
*for asthma + COPD
Asmanex
mometasone
*discard 45 days after removal from pouch
*for asthma + COPD
Dulera
mometasone + formoterol
*for asthma + COPD
Pulmicort
Pulmicort Flexhaler
budesonide
*DOC during pregnancy
*for asthma + COPD
Symbicort
budesonide + formoterol
*good for 90 days after opening foil wrap
[MDI]
*for asthma + COPD
Qvar Redihaler
beclomethasone
*do not use a spacer
*prime or shake
*for asthma + COPD
[breath-actuated aerosol inhaler]
Serevent
salmeterol
*expires 6w after opening
*for asthma + COPD
Singulair
montelukast
*oral granules cannot be mixed in any liquid other than baby formula or breast milk
*can cause flu-like symptoms, mood changes, and restlessness
*for asthma + COPD
Accolate
zarfirlukast
*EAT LATER
*must be taken on empty stomach
*for asthma + COPD
Zyflo CR
zileuton
*LFT
*for asthma + COPD
Atrovent HFA
ipatropium
*anticholinergic
*shaking NOT needed
*solution
*for COPD
Combivent Respimat
ipatropium + albuterol
*anticholinergic
*respimat (PTOP)
*shaking not needed
*discard 3m after cartridge inserted
*for COPD
DuoNeb
ipatropium + albuterol
*anticholinergic
*for COPD
Spiriva HandiHaler
Spiriva Respimat
tiotropium
*anticholinergic
*Handihaler: inhale 1 capsule QD
*Spiriva Respimat: inhale 2 puffs QD
*for COPD
Incruse Ellipta
umeclidinium
*anticholinergic
*Ellipta: dry powders
*NO SHAKING
*NO PRIMING
*discard 6w after removal from foil
*for COPD
Tudorza
aclidinium
*anticholinergic
*NO SHAKING
*Discard after 45d after removal from pouch
*for COPD
Seebri Neohaler
Lonhala Magnair
glycopyrrolate
*anticholinergic
*reversal of bradycardia: IV(Rubinul, Glyrx-P)
IM used for reduction of secretions
PO(Glycate, Cuvposa-soln) used for drooling and hyperhidrosis
*for COPD
Striverdi Respimat
olodaterol
*for COPD
Striverdi Respimat
Perforomist
formoterol
*requires refrigeration and is not mixed with other drugs
*for COPD
Advair
Wixela
fluticasone + salmeterol
*after opening, good for 30d
*for COPD
Breo Ellipta
fluticasone + vilanterol
*Ellipta formulation expires 6w after removal from pouch
*for COPD
Anoro Ellipta
umeclidinium + vilanterol
*Ellipta formulation expires 6w after removal from pouch
*for COPD
Stiolto Respimat
olodaterol + tiotropium
*for COPD
Trilogy Ellipta
fluticasone + umeclidinium + vilanterol
*Ellipta formulation expires 6w after removal from pouch
*for COPD
Daliresp
roflumilast
*QD
*CI in liver impairment
*3A4 substrate; suicidal events; wt loss
*for COPD
Daliresp
roflumilast
*QD
*CI in liver impairment
*3A4 substrate; suicidal events; wt loss
*for COPD
Entresto
Sacubitril + valsartan
*dont give within 36 hours of ACEinhibitor
Entresto
Sacubitril + valsartan
Apidra
glulisine
*RT 28 d
*vials: 100u/ml (10ml) = 1000u/vial
*pens: 100u/ml (3ml) = 300 u/pen
[Rapid acting] : Clear
Humalog
lispro
*RT 28 d
*vials: 100u/ml (10ml) = 1000u/vial
*pens: 100u/ml (3ml) = 300 u/pen
[Rapid acting] : Clear
Novolog
aspart
*RT 28 d
*vials: 100u/ml (10ml) = 1000u/vial
*pens: 100u/ml (3ml) = 300 u/pen
[Rapid-acting] : Clear
Humulin R
Novolin R
Insulin regular
*Humulin R: RT 31d
*Novolin R: RT 42d
[Short-acting] : Clear
Humulin N
Novolin N
insulin NPH (OTC)
*Humulin N: RT 31d
*Novolin N: RT 42d
[Intermediate acting] Cloudy
Levemir
determir
*RT 42d
[Basal] (long acting)
Lantus
Basaglar
glargine
*Lantus: RT 28d
*DO NOT MIX with other insulin
[Basal] (long acting)
Novolog
degludec
*RT 56d
*DO NOT MIX with other insulin
[Basal] (long acting)
SymlinPen
pramlinitide
*SQ TID immediately before meals
Glucophage (XR)
metformin
Glucophage (XR)
metformin
*hold metformin if contrast dye 48h after
*CI in patients with CrCl <30ml/min
Glynase
glyburide
*long acting: more hypoglycemia
*avoid ≥ 65 y/o
[Sulfonylureas]
Glucovance
glyburide + metformine
[Sulfonylureas]
Glucovance
glyburide + metformine
Glucotrol (XL)
glipizide
*DOC in renal failure
[Sulfonylureas]
Amaryl
glimepiride
*8mg QD
[Sulfonylureas]
Amaryl
glimepiride
*8mg QD
Actos
pioglitazone
*BBW: HF, fractures, fluid retention, and liver failure
*MAX 45mg QD
[Thiazolidinediones]
Byetta
Bydureon
BCise
exenatide
*bydureon: qw (refrigerate; RT 4w)
*BCise : Suspension : SHAKE 15s
*Byetttea: BID (refrigerate; RT 30d)
[GLP1 agonist]
Victoza
Saxenda
liraglutide
*1.8mg QD for DM
*3mg QD Saxenda for wt loss
*Refrigerate; RT 30d
[GLP1 agonist]
Trulicity
dulaglutide
*dosed weekly
*Refrigerate; RT 14d
[GLP1 agonist]
Trulicity
dulaglutide
*dosed weekly
*Refrigerate; RT 14d
[GLP1
Onglyza
saxagliptin
- ↑risk of HF
*CYP3A4 substrate
[DPP4 inhibitors]
Januvia
sitagliptin
*25, 50, 100 mg QD
*dose adjust in renal
[DPP4 inhibitors]
Nesina
alogliptin
*↑ risk of HF
[DPP4 inhibitors]
Tradjenta
linagliptin
*no dose adjustment renal/hepatic
*CYP3A4 substrate
[DPP4 inhibitors]
Janumet (XR)
sitagliptin + metformin
Kombiglyze XR
saxagliptin + metformin
Kazano
alogliptin + metformin
Invokana
canagliflozin
*QAM
* Do not initiate if GFR < 30
*SE: UTI, ↑LDL, ↑K, ↑Mg, ↑PO4, ↓wt, ↓BP, bone FRACTURE
[SGLT2 Inhibitor]
Jardiance
empagliflozin
*QAM
* Do not initiate if GFR < 30
*SE: UTI, ↑LDL, ↑K, ↑Mg, ↑PO4, ↓wt, ↓BP, bone FRACTURE
[SGLT2 Inhibitor]
Farxiga
dapagliflozin
*FDA approved for HF
*QAM
* Do not initiate if GFR < 45
*SE: UTI, ↑LDL, ↑K, ↑Mg, ↑PO4, ↓wt, ↓BP, bone FRACTURE
[SGLT2 Inhibitor]
Steglatro
ertugliflozin
*QAM
* Do not initiate if GFR < 45
*SE: UTI, ↑LDL, ↑K, ↑Mg, ↑PO4, ↓wt, ↓BP, bone FRACTURE
[SGLT2 Inhibitor]
Does one take penicillin + ampicillin with or without food???
*tk on empty stomach
Moxatag
Amoxil
amoxicillin
*regardless of food
Augmentin
amoxicillin + clavulanate
*w/ FOOD
*suspension must be refrigerated
Zosyn
piperacillin + tazobactam
*ANTIPSUDOMONAL
*CrCl >40: 3.375g q6h
nosocomial pneumonia: 4.5g q6h
*CrCl20-40: 2.25g q6h
nosocomial pneumonia: 4.5g q8h/3.375g q6h
Keflex
cephalexin
Omnicef
cefdinir
*dont refrigerate oral suspension
*seperate from vitamins/antacids
Fortaz
ceftazidime
*ANTIPSEUDOMONAL
*IV/IM
Avycaz
ceftazidime + avibactam
*ANTIPSEUDOMONAL
*IV
*Intra-abdominal infections
*HAP
Ceftriaxone
-coverage
-dose
N. gonorrhoeae treatment mono therapy
<150 kg: 500mg IM x1
≥150 kg: 1g IM x1
IM: gluteal injection
ceftriaxone
Zithromax
Azasite
azithromycin
*Azasite: ophthalmic
*refrigerate - discard after 14d
*DO NOT refrigerate oral suspension
EES
Ery-tab
erythromycin
*most macrolides are strong 3A4 inhibitor : NEVER use in combo with theophylline or warfarin
*refrigerate suspension
Biaxin
Biaxin XL
clarithromycin
*XL with food
Cleocin
clindamycin
*BBW: C difficile colitis
*DO NOT refrigerate suspension
Cubicin
daptomycin
*gram (+)
*SE: neuropathy, myopathy,
*IV in D5W QD
*DO NOT USE for pneumonia (binds to surfactant of lung)
Vancocin
vancomycin
*gram(+)
*SE: neuropathy, ototoxicity, red man syndrome
*IV over 1 hour
gentamicin
-coverage
-SE
gram (-)
SE: ototoxicity, neuropathy
Arikayce
amikacin
*IM,IV 5-7mg/kg/dose q8h
*GFR 10-50: q24-72h
*Peak: UTI 15-20/serious 20-25/ life threatening inf 25-40
*trough: <5-8
Zyvox
linezolid
*PO, IV: 600mg BID
*Monitor: thrombocytopenia (CBC), eyes MAOI, renal
Septra
Bactrim DS
Trimethoprim + sulfamethoxazole
*1:5
*watch for SULFA allergy
*hydrate to ↓ risk of crystalluria
*IV-D5W
*DO not refrigerate
*discard after 6h
MacroBid
Macrodantin
Nitrofurantoin
*UTI
*tk with food
Macrobid: nitrofurantoin monohydrate + macro crystals BID
Macrodantin: nitrofurantoin macrocrystals :PO 50-100mg q6h
Cipro
ciprofloxacin
*ANTIPSEUDOMONAL
*BBW: tendon rupture, peripheral neuropathy, CNS (avoid if seizure history)
*Do NOT use cipro suspension down the NG tube
*indicated for UTI, not CAP
Levaquin
levofloxacin
*ANTIPSEUDOMONAL
*BBW: tendon rupture, peripheral neuropathy, CNS (avoid if seizure history)
Avelox
Vigamox ophthalmic (TID)
moxifloxacin
*ANTIPSEUDOMONAL
*BBW: tendon rupture, peripheral neuropathy, CNS (avoid if seizure history)
*greater risk of QT prolongation
*indicated for CAP, not UTI
Floxin
ofloxacin
*ANTIPSEUDOMONAL
*BBW: tendon rupture, peripheral neuropathy, CNS (avoid if seizure history)
Minocin
Solodyn
minocycline
*avoid in preggo
*CI: patients ≤8 y/o (tooth discoloration)
Vibramycin
Doryx
doxycycline
*avoid in preggo
*CI: patients ≤8 y/o (tooth discoloration)
*use doxy in renal impairment
*Oracea on an empty stomach
Flagyl
metronidazole
*tk ER on empty stomach
MRSA coverage
IV: vancomycin
Vanco-resistant: Ceftaroline, Daptomycin, Linezolid, Tedizolid, Telavacin, Dalbavancin, Oritavancin
PO: Clindamycin, Bactrim, Doxycycline, Minocycline, Linezolid, Tedizolid
VRE
Linezolid, Tedizolid, Daptomycin, Oritavancin, Tigecycline, Quinupristin/Dalfopristin
Pseudomonas coverage
Zosyn , Ceftazidime, Ceftazidime/Avibactam, Cefepime, Ceftolozane/tazo, aztreonam, meropenem, doripenem, imipenem/ cilastatin; gentamycin, tobramycin, amikacin, plazomycin; cipro, levaquin, delafloxacin
anaerobes coverage
amoxicillin/ clavulanate acid, ampicillin/sulbactam, zosyn, cefoxitin, cefotetan, carbapenems, eravacycline, omadacycline, tigecycline, moxiflaxacin, delafloxacin, clindamycin, metronidazole
Tamiflu
oseltamivir
*for influenza, start within 2d of symptoms
75mg BID x 5d
prevention: 75mg qd x7d
Zovirax
acyclovir
*indicated for HSV
*oral: 400mg TID/ 200mg 5 x QD for 7-10d
Valtrex
valacyclovir
*indicated for HSV
*prodrug: 1g BID x7-10d
Diflucan
fluconazole
*single dosing: 150mg tab x 1 for vaginal candidiasis
Nizoral
ketoconazole
*BBW: hepatotoxicity
Mycostatin
nystatin
*oral yeast infection “swish and swallow” 4-5x QD
Lamisil
Terbinafine
*1st line for onychomycosis
*PO (RX)
*250mg QD 6-12w
Sporanox
itraconazole
*for onychomycosis
*PO (RX)
Penlac
ciclopirox
*for onychomycosis
*topical (Rx)
Jublia
efinaconazole
*for onychomycosis
*topical (Rx)
*QD
Kerydin
tavaborole
*for onychomycosis
*topical x48w
Truvada
TDF + emtricitabine
Atripla
efavirenz + emtricitabine + TDF
*empty stomach
Edurant
rilpivirine
Sustiva
Efavirenz
Pifeltro
doravirine
Perseris
Risperidone
-LAI (SQ)
Aristada
Aripiprazole