NAPLEX Flashcards
Bumex
Bumetanide
*Sulfa allergy
*1mg Bumex = 40mg Lasix
Lasix
furosemide
- Protect IV from LIGHT
Maxzide
Diazide
triamterene/ hydrochlorothiazide
Zaroxolyn
metolazone
- thiazide-related that can be used in renal failure
Aldactone
spironolactone
- SE: gynecomastia; HF dose: 50mg QD
Lotensin
benazepril
Vasotec
enalapril
- only ACE that comes in IV form
Zestril
Prinivil
lisinopril
Zestoretic
lisinopril w/ HCTZ
Accupril
quinapril
Altace
ramipril
- only ACEI that comes in capsules
Avapro
irbesartan
Cozaar
losartan
Hyzaar
losartan w/ HCTZ
Diovan
valsartan
Benicar
olmesartan
Micardis
telmisartan
Normodyne
labetalol
- tk with food. safe in preggo
Bystolic
nebivolol
- ↑ nitric oxide (vasodilation)
Tenormin
atenolol
Coreg, Coreg CR
carvedilol
- tk with food
Inderal
propanolol
- tk with food
Lopressor
metoprolol tartrate
*IR - take with food
Toprol XL
metoprolol succinate
- can be split in half
- for HF, start at 12.5mg, ↑ to TD of 200mg/day
Zebeta
bisoprolol
Calan SR
Verelan
Verelan PM
verapamil
*PO/IV for ventricular rate control
*inhibitor/substrate of CYP3A4
Cardizem
Tiazac
Taztia XT
diltiazem
*PO/IV for ventricular rate control
*inhibitor/substrate of CYP3A4
Cardizem, Tiazac, Taztia XT
diltiazem
*PO/IV for ventricular rate control
*inhibitor/substrate of CYP3A4
Norvasc
amlodipine
*substrate of CYP3A4
*weak inhibitor of CYP3A4
Plendil
felodipine
*substrate of CYP3A4
*ER
*do not crush or chew
*QD
Procardia
Procardia XL
nifedipine
*substrate of CYP3A4
Catapres
Catapres TTS
Kapvay
clonidine
*1 patch q7d
Tenex
Intuniv
guanfacine
Tenex → ADHD
Apresoline
hydralazine
*safe in pregnancy
BiDil
Isosorbide dinitrate + hydralazine
*used for HF
Minipress
Prazosin
*short acting
*not for BPH
*only for HTN
[alpha 1-blocker]
Cardura
Cardura XL
doxazosin
*indicated for HTN and BPH
*titrate due to risk of orthostatic ↓BP
[alpha 1-blocker]
Hytrin [brand DSC]
terazosin
*indicated for HTN and BPH
*titrate due to risk of orthostatic ↓BP
[alpha 1-blocker]
Flomax
tamsulosin
*SULFA
*tk 30 min after same meal each day
[alpha 1-blocker]
Rapaflo
silodosin
*QD
*WITH FOOD
*Caps can be opened and sprinkled onto applesauce
[alpha 1-blocker]
Uroxatral
alfuzosin
*tk with same meal each day
[alpha 1-blocker]
Avodart
-dosing
dutasteride
*males: PO: 0.5mg QD alone or in combo with tamsulosin
[5 Alpha-reductase Inhibitor]
Proscar
Propecia
-dosing
finasteride
*proscar: 5mg for BPH
*propecia: 1mg for male pattern baldness
[5 Alpha-reductase Inhibitor]
Lotrel
amlodipine + benazepril
Ziac
bisoprolol + HCTZ
Ziac
bisoprolol + HCTZ
Ziac
bisoprolol + HCTZ
Tarka
verapamil + tandolapril
*with food
Prestalia
amlodipine + perindopril
Exforge
amlodipine + valsartan
Twynsta
amlodipine + telmisartan
Azor
amlodipine + olmesartan
Caduet
amlodipine + atorvastatin
Consensi
amlodipine + celecoxib
isosorbide mononitrate
-dosing
IR: 20mg BID with the 2 doses given 7 hours apart
Isosordil
-when to administer
isosorbide dinitrate
*dont administer around the clock to prevent tolerance; allow nitrate free interval ≥14h (IR) and ≥18h (SR)
*IR : BID : 8AM and 1PM
*TID: 8AM, 1PM, 6PM
Nitrostat
NitroBid
-storage
nitroglycerin
*IV must be in GLASS bottle
Ranexa
-indication
-CI
ranolazine
*indicated for chronic stable angina
*CI: hepatic impairment
Heparin
-dosage form
-monitoring parameters
-doses
*IV/SQ
*IV: monitor Hgb, Hct, platelet, aPTT, signs of bleeding
*Heparin lock flush is intended to maintain IV line open (NOT anticoagulant tx)
*1,2,10,100 units/mL
Lovenox
-monitoring
-dosing
-CI
-antidote
enoxaparin
*monitoring: platelet, hemoglobin , hematocrit, fecal occult blood, bleeding signs, anti-factor Xa levels (as appropriate), serum creatinine at baseline and during tx
*DVT prophylaxis in hip/knee replacement: 30mg SC q12h, start 12-24h post-op for 7-10d
40mg SC QD
CrCl <30: 30 mg SC QD
*DVT prophylaxis in abdominal surgery: 40mg SC QD start 2h pre op no more than 12 days
*DVT treatment: 1mg/kg SC q12h or 1.5mg/kg QD
CrCl <30: 1mg/kg SC QD
*MI/ unstable angina/ thrombolytic adjunct/ PIC: ID 30mg IV single bolus + 1 mg/kg SC q12h w/ aspirin
*CI: pork allergy
*antidote: protamine
Pradaxa
-drug class
-antidote
-storage
dabigatran
*direct thrombin inhibitor: inhibits factor IIa
*antidote: idarucizumab (Praxbind)
*KEEP IN ORIGINAL BOTTLE. Once opened - 4m
Praxbind
idarucizumab
Eliquis
-dosing
-antidote
apixaban
*DOSED BID
*antidote: Andexanet alfa (Andexxa) (IV)
Andexxa
Andexanet alfa
Xarelto
-dosing
-antidote
rivaroxaban
*DVT prophylaxis: Knee (12d) or hip (35d): 10mg QD
*Stroke prophylaxis in non-Valv Afib:
CrCl>50 : 20mg QD with PM meal
*DVT/PE tx: 15mg BID x 21d; then 20mg QD for 3m or +
*Antidote: andexanet alfa (Andexxa) (IV)
Jantoven
-monitor
-antidote
warfarin
*Monitor: INR, Hgb, Hit, hematocrit, bleeding signs
*CYP inhibitors will ↑ INR, CYP inducer ↓ INR
*Antidote: VitK (phytonadione) (Mephyton)
Mephyton
Phytonadione (Vitamin K)
Plavix
-dosing
-drug class
clopidogrel
*LD: 300mg → 75mg QD
*Prodrug: CYP2C19 inhibitor ↓ plavix
[ADP receptor P2Y12 inhibitor] irreversible
Efficient
-dosing
-drug class
prasugrel
*60mg LD →10mg QD
[ADP receptor P2Y12 inhibitor] irreversible
Brilinta
-LD/MD
-BBW
-drug class
ticagrelor
*LD: 180mg (2 x 90mg)
*MD: 90mg BID
*BBW: aspirin dose >100mg reduces effectiveness
[ADP receptor P2Y12 inhibitor] reversible
Aggrenox
dipyridamole + aspirin
*CI: salicylate allergy
Pacerone
Nexterone
Amiodarone
*DI with warfarin (↑INR)
*dont give sofosbuvir
Multaq
dronedarone
*with FOOD
*avoid grapefuit juice
*watch for liver failure and HF
Betapace
Betapace AF
Sotalol
Tikosyn
dofetilide
*PO
*do not use if CrCl <20
*CI w/ HCTZ, citalopram: QT prolongation
Lanoxin
Digitek
Digox
-antidote
digoxin
Antidote: Digifab
Statins Monitoring Parameters
*Lipid Panels
*LFT: at baseline
*Muscle aches: CPK: not routine: if muscle ache
Lipitor
-max dose
atorvastatin
*MAX 80mg
Crestor
-max dose
rosuvastatin
*MAX 40mg except Asians (ID: 5mg/ MAX: 20mg)
Crestor
rosuvastatin
Zocor
-max dose
simvastatin
*MAX 40mg
Vytorin
ezetimibe + simvastatin
Pravachol
-max dose
pravastatin
*least drug interactions
*MAX 80mg
Mevacor
-max dose
lovastatin
*IR with evening meal
*MAX 80mg
Lopid
gemfibrozil
*do not use with statin: ↑ myopathy
Tricor
Lipofen
Antara
Lofibra
fenofibrate
*Lipofen and Antara taken with food