Hyperlipidemia

Question 1

Livalo
Zypitamag

Answer 1

Pitvastatin

Max 4

Question 2

Crestor

Answer 2

Rosuvastatin

M 40
Asians I 5 M 20
CrCl<30 M10

-> men >50/women>60 with CRP ≥2 and 1 ASCVD risk

Question 3

Lipitor

Answer 3

Atorvastatin

M80
does not cause increase bleeding with warfarin

Question 4

Zocor

Answer 4

simvastatin

M40 QPM
CYP3A4 SUBSTRATE
MAX 10 with verapmil and diltiazem
MAX 20 with amiodarone, amlodipine, ranolazine

Question 5

Vytorin

Answer 5

ezetimibe + simvastatin

Question 6

Mevacor
Altoprev

Answer 6

lovastatin

CYP3A4 SUBSTRATTE
MAX 20 with veramil and diltiazem
MAX 40 with amiodarone

Question 7

Pravachol

Answer 7

pravastatin

M80
renal impairment : I10

Question 8

lescol (XL)

Answer 8

fluvastatin

M80
IR: give PM
CYP2C9 substrate: rifampin decrease levels

Question 9

Dose equivalent

Answer 9

pitavastatin 2
rosuvastatin 5
atorvastatin 10
simvastatin 20
lovastatin 40
fluvastatin 80

Pete & Rose Attract Similar Love Potions Frequent
2 5 10 20 40 80

Question 10

Roszet

Answer 10

rosuvastatin + ezetimibe

Question 11

Statins at bedtime

Answer 11

FLoS

Fluvastatin, Lovastatin, Simvastatin
IR only

Question 12

CYP3A4

Answer 12

SAL

Simvastatin
Atorvastatin
Lovastatin

Question 13

CYP2C9

Answer 13

Fluvastatin
Rosuvastatin

Question 14

Zeta

Answer 14

ezetimibe

10mg QD

Question 15

Praluent

Answer 15

alirocumab

SQ q2w - do not shake
adjunct to max tolerated statin
stored in fridge

[PCSK9 Inhibitor]

Question 16

Repatha

Answer 16

evolocumab

SQ
140 q2w or 420 qm - do not shake
adjunct to max tolerated statin

Sureclick: at least 30 minutes out of fridge
HOLD for 15 seconds
Pushtronex: 45 minutes out of fridge
admin/9 minns

[PCSK9 Inhibitor]

Question 17

Repatha

Answer 17

evolocumab

SQ

Question 18

Niacin

Answer 18

vitamin b3

causes flushing and itching
take after MEALS
take ASA 325mg 30-60m prior

Question 19

Colestid

Answer 19

Colestipol

[Bile Acid Sequestrants]
may increase TG
do not use TG ≥ 300

Question 20

Prevalite
Questran

Answer 20

Cholestyramine

[Bile Acid Sequestrants]
may increase TG
do not use TG ≥ 300

Question 21

Welchol

Answer 21

Colesevelam

[Bile Acid Sequestrants]
may increase TG
do not use TG ≥ 300

Question 22

Lopid

Answer 22

gemfibrozil

before meals
may increase warfarin
risk of hypoglycemia with repaglinide

Question 23

Antara

Answer 23

fenofibrate

with food

AVOID if hepatic impairment
AVOID if CrCl ≤ 30

Question 24

Lipofen

Answer 24

fenofibrate

with food

AVOID if hepatic impairment
AVOID if CrCl ≤ 30

Question 25

Tricor
Triglide

Answer 25

Fenofibrate

AVOID if hepatic impairment
AVOID if CrCl ≤ 30

Question 26

Trillpix

Answer 26

Choline fenofibrate

AVOID if hepatic impairment
AVOID if CrCl ≤ 30

Question 27

Fibricor

Answer 27

fenofibric acid

AVOID if hepatic impairment
AVOID if CrCl ≤ 30

Question 28

Lovaza

Answer 28

omega3 acid
(EPA/DHA)

Question 29

Vascepa

Answer 29

Icosapent ethyl (EPA)

BID with food
does not increase LDL

Question 30

Epanova

Answer 30

Omega-3carboxylic acid
(EPA/DHA)

Question 31

Nexletol

Answer 31

Bempedoic acid

Monitor: hyperuricemia, tendon rupture

Simvastatin do not exceed 20
Lovastatin do next exceed 40

Question 32

Evkeeza

Answer 32

Evinacumab (IV)

-> homozygous familial hypercholesterolemia

Question 33

Leqvio

Answer 33

Inclisiran

q6m

-> homozygous familial hypercholesterolemia
-> max tolerated statin