Named Reaction

Question 1

Sharpless expoxidation

Answer 1

Alkene of with allylic alcohol to epoxide.

Question 2

Regitz Diazo transfer

Answer 2

Diazo btw two carbonyls. Can then couple with ROH to form -OR

Question 3

Claisen reaction

Answer 3

Formation of B-keto ester from two esters. Must have same OR group. Solvent must be ROH

Question 4

Cope elimination

Answer 4

Loss of nitrogen (upon reacting with mcpba) with introduction of a-B alkene

Question 5

Pictet Spengler rxn

Answer 5

Rxn of Beta aryl amines with carbonyl to form THIQ

Question 6

Curtius rearrangement

Answer 6

-COOH activated by SOCl2 to give -COCl. Then react with NaN3 to form RCON3, heat to release N2 and form RNCO (rearrange), react with alcohol OR’ to form RNCOOR’

Question 7

Glaser coupling

Answer 7

Coupling of two alkynes with CuCl

Question 8

Mannich reaction?

Answer 8

Formation of beta amino carbonyl by reacting amine, formaldehyde and then enol (acid media) from enolizable carbonyl compound

Question 9

Rubottom Oxidation

Answer 9

Alpha hydroxy carbonyl from silyl enol ethers by using mcPBA

Question 10

Fischer indole synthesis

Answer 10

Aryl hydrazine with ketone/aldehyde to form indole. Strong acid allows indolization at least substituted carbon

Question 11

Von Braun Rxn?

Answer 11

Tertiary amine to secondary amine using ACE-Cl. Aminocyanide formed in the process.

Question 12

Mitsunobu

Answer 12

Alcohol to ester by reacting with -COOH. Reagents needed are DEAD and PPh3

Question 13

Dieckmann condensation?

Answer 13

Basically a intramoleculae claissen condensation to form a cyclic B-keto-ester

Question 14

Claissen rearrangement

Answer 14

Conversion of allyl vinyl ethers to gamma-delta unsaturated carbonyls

Question 15

Strecker amino acid synthesis from aldehydes

Answer 15

React aldehyde with amine to form imine. Treat with KCN to form alpha amino nitrile. React with water and acid to kick out CN and install COOH

Question 16

Beckmann rearrangement

Answer 16

Reaction of ketone to with hydroxyl amine to form amide (or amine after reduction). Use of aldehydes form nitriles. R group anti to LG on N will migrate

Question 17

Hoffmann rearrangement

Answer 17

Convertion of amide to amine but carbonyl carbon leaves. Reagents: NaOCl, heat. Using LTA or hyper iodine reagents yields carbamate.

Question 18

Schmidt reaction

Answer 18

Basically a Beckmann rearrangement but uses R-N3 instead as reagent

Question 19

Bayer Villiger Oxi

Answer 19

Ketone to ester or cyclic ketone to lactone. The group that leaves the carbonyl carbon is in order: 3>2>aryl>1>Me

Question 20

Neber rearrangement

Answer 20

Ketones to alpha amino ketone by reacting with hydroxyl amine. Amine ends up on more E+ methylene

Question 21

Finkelstein rxn

Answer 21

Alkyl halide or R-OMs/R-OTs to new alkyl halide

Question 22

Hydroboration oxidation

Answer 22

Alkene to alcohol. Syn addition. Anti markovnikov hence OH on least sub carbon.

Question 23

Addition of H-X to alkenes

Answer 23

Markovnikov. Halogen ends up on most substituted carbon