Amine Formation

Question 1

Amine from carbonyl?

Answer 1

Reductive amination (imine first, then reductn to amine)

Question 2

Amine from acid chloride?

Answer 2

React with NH3 to kick out Cl, reduce with LiAlH4

Question 3

Amine from nitrile?

Answer 3

Reduction of nitrile with LiAlH4

Question 4

Amine from a-b unsaturated ketones/carbonyls?

Answer 4

Michael addition with Amine. Enol forms which tautomerizes to form ketone

Question 5

From azide?

Answer 5

Staudinger reduction using PPh3 and water

Question 6

From R-X?

Answer 6

React with NaN3 to form azide, then reduce via staudinger