Naloxone Hydrochloride (narcan)

Question 1

naloxone hydrochloride (Narcan)
class:

Answer 1

Opioid antagonist, opioid reversal agent, antidote

Question 2

naloxone hydrochloride (Narcan)
Pharmacology and action

Answer 2

Competitive inhibition at opioid receptor sites. Reverses opioid-induced
respiratory depression and sedation

Question 3

naloxone hydrochloride (Narcan)
onset,duration, peak effect

Answer 3

Onset: <2 minutes IV. 2-10 minutes IM/IN Duration: 20 minutes-2 hours IV/IM/IN
Peak Effect: Less than 2 minutes IV. 2-10 minutes IM/IN

Question 4

naloxone hydrochloride (Narcan)
indications and contraindications

Answer 4

Indications
● Opioid-induced respiratory depression
IV. Contraindications
● Neonates of opioid-addicted mothers (relative)
● Opioid dependency (relative)

Question 5

naloxone hydrochloride (Narcan)
Adverse reactions and side effects

Answer 5

Cardiovascular: Hypertension/hypotension with rapid administration, dysrhythmias
Neurological: Restlessness, seizures, withdrawal symptoms in opioid-dependent patients
Respiratory: dyspnea, pulmonary edema
Other: Diaphoresis

Question 6

naloxone hydrochloride (Narcan)
Dosage

Answer 6

Adult: Initial dose of 0.4-2mg IV/IO/IM/ETT or up to 4mg IN.
Pediatric: Initial dose of 0.1 mg/kg IV/IO/IM/IN/ETT. Max dose: 2mg IV/IM/ETT or 4mg IN.

Question 7

naloxone hydrochloride (Narcan)
Special considerations

Answer 7

● Generally not beneficial in cardiac arrest

Question 8

naloxone hydrochloride (Narcan)
Drug interactions

Answer 8

● Incompatible with bisulfate and alkaline solutions