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MT 6314 (3rd Shifting) > NA-FASI-Antimyco Rationale > Flashcards

NA-FASI-Antimyco Rationale Flashcards

1
Q

Which is/are respiratory quinolones:

Moxifloxacin
Levofloxacin
Both
Neither

A

Both

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2
Q

Adverse reaction of crystalluria is associated with

A

Sulfonamide

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3
Q

Adverse reaction of ototoxicity is associated with

A

Capreomycin

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4
Q

Activity against Mycobacterium tuberculosis:

Levoflaxacin _ Ciprofloxacin

A

Levoflaxacin > Ciprofloxacin

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5
Q

Which is/are bacteriostatic

Isoniazid
Rifampin
Both
Neither

A

Neither

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6
Q

Clinically used for treatment of chlamydial urethritis:

A

Levofloxacin

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7
Q

TRUE OR FALSE

Trimethoprim-sulfamethoxazole is the drug of choice for toxoplasmosis.

A

TRUE

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8
Q

Which is/are respiratory quinolones:

Gemfloxacin
Ciprofloxacin
Both
Neither

A

Gemfloxacin
Moxifloxacin

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9
Q

Adverse effect of nephrotoxicity is associated with:

Ethionamide
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

A

Capreomycin

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10
Q

Which is/are bacteriostatic

Isoniazid
Ethambutol
Pyrazinamide

A

Ethambutol
Pyrazinamide

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11
Q

Classify: Sulfamethoxazole

Oral Absorbable Sulfonamide
Oral Nonabsorbable Sulfonamide
Topical Sulfonamide

A

Oral Absorbable Sulfonamide

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12
Q

Which is/are respiratory quinolones:

Moxifloxacin
Ciprofloxacin
Both
Neither

A

Moxifloxacin

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13
Q

Which is/are hepatotoxic:

Pyrazinamide
Rifampin
Both
Neither

A

Pyrazinamide

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14
Q

Which is/are generally bactericidal?

Ethambutol
Rifampin
Both
Neither

A

Rifampin

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15
Q

Mechanism of action of Trimethoprim

Inhibits topoisomerase IV
Inhibits dihydropteroate synthase
Both
Neither

A

Neither

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16
Q

TRUE or FALSE

Sulfonamides stimulates growth Rickettsiae

A

TRUE

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17
Q

Adverse effect of granulocytopenia is associated with:

Ethionamide
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

A

Aminosalicylic Acid

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18
Q

Adverse reaction of Steven-Johnson syndrome is associated with:

Sulfonamide
Trimethoprim
Ciprofloxacin

A

Sulfonamide

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19
Q

This inhibits RNA synthesis by binding to bacterial DNAdependent RNA pol

Isoniazid
Rifampin
Pyrazinamide
Ethambutol
Streptomycin

A

Rifampin

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20
Q

Adverse reaction of hemolytic anemia is associate with:

Sulfonamide
Trimethoprim
Ciprofloxacin

A

Sulfonamide

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21
Q

Anti-leprosy drug which can cause hemolysis in G6PD deficient patients

Dapsone
Clofazimine
Rifampin
Isoniazid

A

Dapsone

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22
Q

This disrupts mycobacterial cell membrane

Isoniazid
Rifampin
Pyrazinamide
Ethambutol
Streptomycin

A

Pyrazinamide

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23
Q

Mechanism of Action of Sulfonamides

Inhibits DNA gyrase
Inhibits topoisomerase IV
Both
Neither

A

Neither

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24
Q

TRUE or FALSE

Trimethorpim-sulfamethoxazole is the drug of choice for nocardiosis

A

TRUE

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25
Q

Mechanism of action of Quinolones

Inhibits DNA gyrase
Inhibits dihydrofolate reductase
inhibits topoisomerase IV

A

Inhibits DNA gyrase
inhibits topoisomerase IV

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26
Q

Hepatic biotransformation of absorbed sulfonamide includes:

Sulfation
Acetylation
Methylation
Glucoronidation

A

Acetylation
Glucoronidation

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27
Q

Which drug combination is used to treat falciparum malaria:

Sulfamethoxazole + Trimethoprim
Sulfadiazine + Pyrimethamine
Clofazimine + Pyrazinamide
Sulfadoxine + Pyrimethamine

A

Sulfadoxine + Pyrimethamine

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28
Q

Drug of choice for prophylaxis against disseminated M. avium complex MAC

Azithromycin
Clarithromycin
Rifabutin

A

Azithromycin
Clarithromycin
Rifabutin din ata

lahat ba?

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29
Q

Clinically used for menigococcal carrier:

Ciprofloxacin
Levofloxacin
Both
Neither

A

Ciprofloxacin
Levofloxacin

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30
Q

Drug of choice for treatment of anthrax:

Ciprofloxacin
Levofloxacin
Norfloxacin
Ofloxacin

A

Ciprofloxacin

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31
Q

Clinically used for treatment of gonococcal infection:

Ciprofloxacin
Levofloxacin
Both
Neither

A

Neither

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32
Q

Which can cross the blood brain barrier with inflammed meninges

Pyrazinamide
Ethambutol
Rifampin
Isoniazid

A

Pyrazinamide
Ethambutol
Isoniazid

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33
Q

** Clinically used to treat tuberculosis in patients with HIV infection on antiretroviral therapy
**

Rifabutin
Rifapentin
Both
Neither

A

rifabutin

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34
Q

Adverse effect of QTc interval prolongation is associated with:

Gemfloxacin
Moxifloxacin
Both
Neither

A

Gemfloxacin
Moxifloxacin
Levofloxacin

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35
Q

Oral sulfisoxazole is indicated for:

Simple urinary tract infections
Ocular infections
Burn infections
Ulcerative colitis or rheumatoid arthritis
Toxoplasmosis

A

Simple urinary tract infections

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36
Q

“Megaloblastic anemia, leukopenia, and granulocytopenia are predictable adverse effects of:”

Sulfonamide
Trimethoprim
Beta-lactam
Quinolone

A

Trimethoprim

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37
Q

MOA is mycolic acid synthesis inhibitor

Ethionamide
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

A

Ethionamide

38
Q

MOA is protein synthesis inhibitor

Ethionamide
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

A

Capreomycin

39
Q

Which is active against intracellular tubercle bacilli

Isoniazid
Pyrazinamide
Both
Neither

40
Q

Clinically used for treatment of chlamydial urethritis:

Ofloxacin
Levofloxacin
Both
Neither

41
Q

TRUE or FALSE

Trimethoprim inhibits the secretion of creatinine in the distal renal tubule

42
Q

As antimetabolites of PABA, there are competitive inhibitors of dihydropteroate synthase

Sulfonamide
Trimethoprim
Pyrimethamine
Quinolone

A

Sulfonamide

43
Q

Which is/are hepatotoxic

Isoniazid
Pyrazinamide
Both
Neither

44
Q

Activity against atypical mycobacteria

Levofloxacin > Ciprofloxacin
Levofloxacin < Ciprofloxacin
Levofloxacin = Ciprofloxacin

A

Levofloxacin > Ciprofloxacin

45
Q

TRUE or FALSE

Silver sulfadiazine is more toxic topical sulfoniamide than mafenide

46
Q

Acute hemolysis in patients with glucose-6-phosphate
dehydrogenase deficiency is observed with:

Sulfonamide
Trimethoprim
Beta lactam
Quinolone

A

Sulfonamide

47
Q

Absorbed Sulfonamides are removed from the body by:

Urinary glomerular filtration
Biliary excretion
Both
Neither

A

Urinary glomerular filtration

48
Q

Adverse reaction of Drug-induced systemic lupus erythematosus is associated with:

Isoniazid
Rifampin
Pyrazinamide
Ethambutol
Streptomycin

49
Q

Which is/are enzyme inhibitor

Isoniazid
Pyrazinamide
Both
Neither

50
Q

Which is/are enzyme inducer

Ethambutol
Rifampin

51
Q

Adverse reaction of red-green color blindness is associated with:

Isoniazid
Rifampin
Pyrazinamide
Ethambutol
Streptomycin

A

Ethambutol

52
Q

Anti-leprosy drug which can cause erythrema nodosum leprosum

Dapsone
Clofazimine
Rifampin
Isoniazid

53
Q

Anti-leprosy drug which can cause Methemoglobinemia

Dapsone
Clofazimine
Rifampin
Isoniazid

54
Q

This inhibits arabinoglycan polymerization by binding to
arabinosyl transferase

Isoniazid
Rifampin
Pyrazinamide
Ethambutol
Streptomycin

A

Ethambutol

55
Q

Activity against M. tuberculosis

Moxifloxacin < Levofloxacin
Moxifloxacin > Levofloxacin
Moxifloxacin = Levofloxacin

A

Moxifloxacin > Levofloxacin

56
Q

Adverse reaction of acute tubular necrosis is associated with

Isoniazid
Rifampin
Pyrazinamide
Ethambutol
Streptomycin

57
Q

TRUE or FALSE

fluoroquinolones were originally developed against Gram-positive aerobic bacteria

58
Q

Granulocytopenia, thrombocytopenia, and aplastic anemia is a hematologic toxicity of:

Sulfonamide
Trimethoprim
Beta lactam
Quinolone

A

Sulfonamide

59
Q

This inhibits mycolic acid synthesis by binding to beta-ketoacyl protein synthetase

Isoniazid
Rifampin
Pyrazinamide
Ethambutol
Streptomycin

60
Q

TRUE or FALSE

Trimethoprim is less lipid-soluble than sulfamethoxazole.

61
Q

Clinically used against Shigellosis for children

TMP-SMZ
Ciprofloxacin
Both
Neiter

A

Ciprofloxacin

62
Q

Adverse effect of cardiac toxicity is associated with

Ethionamide
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

A

Bedaquiline

63
Q

Oral triple sulfa is indicated for:

Simple urinary tract infections
Ocular infections
Burn infections
Ulcerative colitis or rheumatoid arthritis
Toxoplasmosis

A

Simple urinary tract infections

64
Q

TRUE or FALSE

Topoisomerase IV inhibition prevents the relaxation of
supercoiled DNA.

65
Q

MOA is cell wall synthesis inhibitor

Ethionamide
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

A

Cycloserine

66
Q

MOA is folate synthesis inhibitor

Ethionamide
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

A

Aminosalicylic Acid

67
Q

Adverse reaction of hyperuricemia is associated with

Isoniazid
Rifampin
Pyrazinamide
Ethambutol
Streptomycin

A

Pyrazinamide

68
Q

TRUE or FALSE

Lomefloxacin may cause photosensitivity.

69
Q

TRUE or FALSE

Trimethoprim-sulfamethoxazole is the drug of choice for Pneumocystis pneumonia.

70
Q

This is administered to minimize bone marrow suppression caused by pyrimethamine

Clofazimine
Pyridoxine
Plazomicin
Leucovorin

A

Leucovorin

71
Q

Activity against M. tuberculosis

Levofloxacin > Ciprofloxacin
Levofloxacin < Ciprofloxacin
Levofloxacin = Ciprofloxacin

A

Levofloxacin > Ciprofloxacin

72
Q

This is an inhibitor of dihydrofolate reductase

pyrimethamine
sulfonamide
quinolone
beta lactam

A

pyrimethamine

73
Q

Adverse effect of crystalluria is associated with

Ethionamide
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

A

Aminosalicylic Acid

74
Q

This weakly acidic compound that have a common chemical nucleus resembling p-aminobenzoic acid (PABA)

sulfonamide
trimethoprim
pyrimethamine
quinolone

A

sulfonamide

75
Q

Adverse reaction of crystalluria is associated with

Sulfonamide
Trimethoprim
Ciprofloxacin

A

Sulfonamide

76
Q

Hepatic biotransformation of absorbed sulfonamide includes

methylation
glucuronidation
both
neither

A

glucuronidation

77
Q

Anti-leprosy drug which can be used to treat Pneumocystis jiroveci in AIDS patients

Dapsone
Clofazimine
Rifampin
Isoniazid

78
Q

Anti-leprosy drug which inhibit folate synthesis

Dapsone
Clofazimine
Rifampin
Isoniazid

79
Q

Which has the longest half-life?

Ofloxacin
Levofloxacin
Moxifloxacin
Gemifloxacin

A

Moxifloxacin

80
Q

Anti-leprosy drug which can cause discoloration of the skin

Dapsone
Clofazimine
Rifampin
Isoniazid

A

Clofazimine

81
Q

TRUE or FALSE

Pseudomonas is intrinsically resistant to sulfonamides.

82
Q

Clinically used against UTI for children

TMP-SMZ
Ciprofloxacin
Both
Neither

83
Q

Classify: Sulfadiazine-pyrimethamine

Oral Absorbable Sulfonamide
Oral Nonabsorbable Sulfonamide
Topical Sulfonamide

A

Oral Absorbable Sulfonamide

84
Q

Adverse effect of psychosis is associated with

85
Q

Mechanism of action of Sulfonamides

inhibits topoisomerase IV
inhibits dihydropteroate
synthase
Both
Neither

A

inhibits dihydropteroate
synthase

86
Q

Adverse effect of depression is associated with

Ethionamid
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

A

Cycloserine

87
Q

Oral sulfa-salazine is indicated for:

Simple urinary tract infections
Ocular infections
Burn infections
Ulcerative colitis or rheumatoid arthritis
Toxoplasmosis

A

Ulcerative colitis or rheumatoid arthritis

88
Q

Which is nephrotoxic

Sulfonamide
Trimethoprim
Both
Neither

A

Sulfonamide

89
Q

This selective inhibitor of bacterial dihydrofolate reductase
that prevents formation of the active tetrahydro form of folic
acid

trimethoprim
sulfonamide
beta lactam
quinolone

A

trimethoprim

90
Q

**TRUE or FALSE **

Sulfonamides stimulates growth of Ricketsiae.

MT 6314 (3rd Shifting) (7 decks)

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