mysthenia gravis Flashcards
What is the pathophysiology of MG?
It is an autoimmune disease where antibodies are made which block the acetylcholine receptors for muscles so they cannot contract.
Why do you do a CT of chest for MG?
In case of thyoma which can be acuse of MG
What are the symptoms of MG?
- fatigueability ie worse with activity and better with rest
- ptosis
- dipolpia
- dysphagia
- slurred speech
- weakness
- if severe can have difficulty breathing- SOB
What is most commonly affected first in MG?
The eyes
What are the investigations for MG?
A blood test can detect the abnormal antibody and confirm the diagnosis in most cases.
Muscle and nerve tests may be needed in some cases where the diagnosis is not clear.
CT thymus
Breathing tests are performed in those people who have weakness of the chest muscles.
What is the management for MG?
acetylcholinesterases eg pyridostigmine.- first line
thymectomy
steroids eg prednisolone
immunosupressant eg azothiaprine
What is a myasthenic crisis?
A myasthenic crisis occurs when the muscles that control breathing weaken to the point that breathing becomes very difficult. Admission to hospital is usually needed and sometimes assisted breathing by a ventilator machine is performed for a short while.
What is the managemet for a myasthenic crisis?
plasma exchange, ventilation, oxygen
Are reflexes intact in MG?
yes - as is not an UMN or LMN issue
