myRisk Gene Groups & Associated Cancers

Question 1

Breast, Ovarian, Pancreatic, Prostate, Melanoma*

Answer 1

BRCA1 & BRCA2*

Question 2

Ovarian, Colorectal, Endometrial, Pancreatic, Gastric, Prostate, Other

Answer 2

MLH1, MSH2, MSH6, PMS2, EPCAM

Question 3

Colorectal, Pancreatic, Gastric, Other

Answer 3

APC, BMPR1A, SMAD4

Question 4

Colorectal, Other*

Answer 4

MUTYH Biallelic*, MUTHY Monoallelic, POLD1, POLE, GREM1, AXIN2, GALNT12, RPS20, RNF43, NTHL1 Biallelic, MSH3 Monoallelic

Question 5

Melanoma, Pancreatic

Answer 5

CDKN2A (p16INK4a), CDKN2A (p14ARF), CDK4

Question 6

Breast, Ovarian, Colorectal, Endometrial, Melanoma, Pancreatic, Gastric, Prostate, Other

Answer 6

TP53

Question 7

Breast, Colorectal, Endometrial, Melanoma, Other

Answer 7

PTEN

Question 8

Breast, Ovarian, Colorectal, Endometrial, Pancreatic, Gastric, Other

Answer 8

STK11

Question 9

Breast, Colorectal, Gastric

Answer 9

CDH1

Question 10

Breast, Pancreatic

Answer 10

PALB2, ATM

Question 11

Breast, Colorectal

Answer 11

CHEK2

Question 12

Breast, Prostate

Answer 12

NBN

Question 13

Ovarian

Answer 13

BRIP1, RAD51C, RAD51D

Question 14

Prostate

Answer 14

HOXB13

Question 15

What is the difference in associated cancers between BRCA1 and BRCA2?

Answer 15

BRCA2 mutation includes risk fo melanoma, while BRCA1 does not.

Question 16

What is the difference between Bilallelic and Monoallelic mutations in NTHL1 and MSH3?

Answer 16

Biallelic mutations in both genes have associated cancers (Colorectal), while monoallelic mutations simply mean you are a carrier.