Myositis Flashcards
1
Q
Severe myopathy with dysphagia, facial weakness
A
SRP
2
Q
Necrotizing myopathy
A
SRP
HMG-CoA (Statin) (200/100 kDa)
3
Q
Inclusion body
A
NT5C1A
CN1A
4
Q
Anti-synthetase (8)
A
Mechanic’s hands, Raynaud’s, Arthritis, Lung disease
Jo-1 (histidyl tRNA synthetase)
PL-7 (threonyl)
PL-12 (alanyl)
EJ (glycyl)
OJ (isoleucyl)
Ha
ZO
KS
5
Q
MDA5
A
Rapidly progressive lung disease, skin disease, amyopathic
6
Q
CTD-overlap (6)
A
Ku, U1-RNP, U3RNP (fibrillin), Ro/La, PmScl
7
Q
Skin disease associated (5)
A
SAE (small ubiquitin, SUMO)
Mi-2 (NuRD)
MDA5 (CADM-140)
NXP2 (MJ, p140)
TIF-1 (p155/140)
8
Q
Calcinosis
A
NXP2 (MJ, p140)
9
Q
Malignancy
A
NXP2 (MJ, p140)
TIF1 (p155/140)
Mi-2 and Anti-synthetase (negative association)
Ulcerative Skin lesions highly associated w/malignacy
