Lupus Nephritis

Question 1

Class 1

Answer 1

AKA: minimal mesangial

Mesangial immune deposits

Question 2

Mesangial immune deposits

Answer 2

Class 1

AKA minimal mesangial

Question 3

Class 2

Answer 3

AKA mesangial proliferative

Mesangial hypercellularity or mesangial matrix expansion, few subepithelial/subendothelial deposits by IF/EM

Question 4

Mesangial hypercellularity or mesangial matrix expansion, few subepithelial/subendothelial deposits by IF/EM

Answer 4

Class 2

AKA mesangial proliferative

Question 5

Class 3

Answer 5

AKA focal

Light: segmental poliferation wire loops, some areas of cellular hyperproliferation and some areas spared

EM: mesangial immune deposits

Almost Uniform immunofluorescence

Question 6

Light: segmental poliferation wire loops, some areas of cellular hyperproliferation and some areas spared

EM: mesangial immune deposits

Almost Uniform immunofluorescence

Answer 6

Class 3

AKA focal

Question 7

Class 4

Answer 7

AKA diffuse

Immunofluorescence full house, extensive

Light: hypercellularity of mesangial area and early crescent

EM: immune complexes in subepithelial and subendothelial

Question 8

Immunofluorescence full house, extensive

Light: hypercellularity of mesangial area and early crescent

EM: immune complexes in subepithelial and subendothelial

Answer 8

Class 4

Diffuse

Question 9

Class 5

Answer 9

AKA membranous

Granular global or segmental subepithelial immune dposits by IF or EM

Question 10

Class 6

Answer 10

Advanced sclerosing

> 90% global glomerulosclerosis