Myocardial ischemia

Question 1

definition

Answer 1

reversible

inadequate blood supply to heart

Question 2

Causes

Answer 2

fixed coronary stenosis
increased myocardial demand
coronary vasospasm
intraplaque hemorrhage
superimposed thrombosis
combination of these factors

Question 3

stunned myocytes

Answer 3

myocytes injured by acute ischemia

look normal microscopically, but need time to repair before they work normally again

Question 4

hibernating myocytes

Answer 4

chronically ischemic myocytes

cleared cytoplasm due to catabolism of their contractile proteins

Question 5

Myocytolysis

Answer 5

light microscopic appearance of hibernating myocytes

Question 6

ischemic preconditioning

Answer 6

resistance to mild to moderate ischemia due to induction of protective proteins by brief episodes of ischemia

Question 7

contraction band necrosis

Answer 7

dead myocytes with dense hypereosionphilic transverse bands of hypercontracted sarcomeres associated w/ reperfusion

Question 8

no-reflow phenomenon

Answer 8

failure of relieving obstruction at arterial level to restore blood flow…atributed to microvascular obstruction or edema

Question 9

reperfusion injury

Answer 9

hemorrhage and other injurious phenomena associated w/ bringing O2 and calcium to injured tissue…attributed to ROS and metabolic effects of calcium