Myocardial Infarction Flashcards

1
Q

What is myocardial infarction(heart attack)?

A

An acute coronary syndrome which describes the short term and long term changes as blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.
Refers to tissue death (infarction) of the heart muscle (myocardium).

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2
Q

Common symptoms of heart attack?

A
Chest pain (left or center, is most common) with nausea, sweating, vomiting, fainting or discomfort which may travel into the shoulder, arm, back, neck, upper abdomen or jaw. The discomfort may occasionally feel like heartburn.
Other symptoms: shortness of breath, nausea, feeling faint, a cold sweat, palpitations, ab-normalcy in heart or feeling tired
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3
Q

What can MI cause?

A

Can cause heart failure, an irregular heartbeat, cardiogenic shock, tissue death or cardiac arrest
Most occur because of coronary artery disease.
Heart with a limited blood supply subject to increased oxygen demands, such as in fever, a fast heart rate, hyperthyroidism, less red blood cells in the bloodstream, or low blood pressure. Damage or failure of procedures such as percutaneous coronary intervention or coronary artery bypass grafts

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4
Q

What are some risk factors of MI?

A

High blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, male sex, low levels of physical activity, a past family history, tobacco smoking and obesity
High levels of blood cholesterol is a known risk factor, particularly high low-density lipoprotein, low high-density lipoprotein, and high triglycerides

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5
Q

What is the underlying mechanism of MI?

A

The complete blockage of a coronary artery caused by a rupture of an atherosclerotic plaque

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6
Q

What are tests used to diagnose MI?

A

ECGs, blood tests, and coronary angiography
An ECG, which is a recording of the heart’s electrical activity, may confirm an ST elevation MI (STEMI) if ST elevation is present. Commonly blood tests include troponin and less often creatine kinase MB

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7
Q

What is the immediate treatment for MI?

A

Aspirin is an appropriate immediate treatment for a suspected MI. Beta blockers and statin are recommended after MI.
Nitroglycerin or opioids may be used to help with chest pain but they do not improve overall outcomes.
Supplemental oxygen should be used in those with low oxygen levels or shortness of breath.

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8
Q

What are the treatments for STEMI which restores blood flow to the heart?

A

Percutaneous coronary intervention (PCI), where the arteries are pushed open and may be stented Thrombolysis, where the blockage is removed using medications

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9
Q

What are the treatments for people with NSTEMI?

A

Non-ST elevation myocardial infarction (NSTEMI) use blood thinner heparin, with the additional use of PCI in those at high risk.

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10
Q

What are treatments for people with blockages of multiple coronary arteries and diabetes?

A

Coronary artery bypass surgery (CABG) may be recommended rather than angioplasty.

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11
Q

When does MI occur and how is it measured and classified?

A

Occurs when there is cell death, as measured by a blood test of cardiac enzymes such as troponin or CK-MB. When there is evidence of an MI, it may be classified as an ST elevation myocardial infarction (STEMI) or Non-ST elevation myocardial infarction (NSTEMI) based on the results of an ECG.

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12
Q

How is MI different from heart attack?

A

An MI is different from—but can cause—cardiac arrest, where the heart is not contracting at all or so poorly that all vital organs cease to function, thus causing death. It is also distinct from heart failure, in which the pumping action of the heart is impaired. However, an MI may lead to heart failure.

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13
Q

What is Levine’s sign?

A

A person localizes the chest pain by clenching one or both fists over their sternum, thought to be predictive of cardiac chest pain.

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14
Q

Pain that responds to what does not indicate the presence or absence of MI?

A

Nitroglycerin

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15
Q

Which symptom of MI occurs when damage to the heart limits the output of the left ventricle, with breathlessness arising either from low oxygen in the blood, or pulmonary edema?

A

Shortness of breath.

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16
Q

Why do the symptoms occur for MI?

A

Pain and Low Blood Pressure = A massive surge of Catecholamines from the sympathetic nervous system, Loss of consciousness: inadequate blood flow to the brain
Cardiogenic shock, and sudden death: the development of ventricular fibrillation.
Cardiac arrest, and atypical symptoms such as palpitations, occur more frequently in women, the elderly, those with diabetes, in people who have just had surgery, and in critically ill patients

17
Q

How are silent MIs discovered?

A

Discovered later on electrocardiograms, using blood enzyme tests, or at autopsy after a person has died
Common in elderly with diabetes mellitus and after heart transplantation.
In people with diabetes, differences in pain threshold, autonomic neuropathy, and psychological factors have been cited as possible explanations for the lack of symptoms.
In heart transplantation, the donor heart is not fully innervated by the nervous system of the recipient.

18
Q

How many genetic variants are there for MI?

A

27 genetic variants that are associated with an increased risk of mi The strongest association of MI has been found with chromosome 9

19
Q

What is the common cause of MI?

A

Rupture of an atherosclerotic plaque(Cholestrol, fats and fibrous tissue) on an artery supplying heart muscle.

20
Q

What are the complications of MI?

A

Atrial fibrillation, ventricular tachycardia, fibrillation and heart block, stroke is also a risk, either as a result of clots transmitted from the heart during PCI, as a result of bleeding following anticoagulation, or as a result of disturbances in the heart’s ability to pump effectively as a result of the infarction.
Regurgitation of blood through the mitral valve is possible, particularly if the infarction causes dysfunction of the papillary muscle.
Cardiogenic shock
Rupture of the ventricular dividing wall or left ventricular wall may occur within the initial weeks
Dressler’s syndrome
Heart failure may develop as a long-term consequence, with an impaired ability of heard muscle to pump, scarring, and increase in size of the existing muscle. Aneurysm of the left ventricle myocardium[

21
Q

What is the primary prevention for MI?

A

Healthy lifestyle, polyunsaturated fats, using statins which lower blood pressure

22
Q

What is the secondary prevention for MI?

A

Following a heart attack, nitrates, when taken for two days, and ACE-inhibitors decrease the risk of death. Aapirin, beta blocker, ACE inhibitor, Statin, Aldosterone antagonists, Defribrillator

23
Q

What is the management for MI?

A

Pain: treated with Nitroglycerine or morphine
Anticoagulation: Aspirin
Percutaneous coronary intervention (PCI): involves small probes, inserted through femoral artery or radial artery into the blood vessels of the heart. The probes clear blockages using small balloons, which are dragged through the blocked area
Fibrinolysis and Cardiac Rehabilitation

24
Q

How is acute MI defined by elevated marker?

A

Symptoms relating to ischemia
Changes on an electrocardiogram (ECG), such as ST segment changes, new left bundle branch block, or Q waves
Changes in the motion of the heart wall on imaging
Demonstration of a thrombus on angiogram or at autopsy.

25
Q

5 Specific Classifications for MI

A

Spontaneous MI related to plaque erosion and/or rupture, fissuring, or dissection
MI related to ischemia, such as from increased oxygen demand or decreased supply, e.g. coronary artery spasm, coronary embolism, anemia, arrhythmias, high blood pressure or low blood pressure
Sudden unexpected cardiac death, including cardiac arrest, where symptoms may suggest MI, an ECG may be taken with suggestive changes, or a blood clot is found in a coronary artery by angiography and/or at autopsy, but where blood samples could not be obtained, or at a time before the appearance of cardiac biomarkers in the blood
Associated with coronary angioplasty or stents
Associated with percutaneous coronary intervention (PCI)
Associated with stent thrombosis as documented by angiography or at autopsy
Associated with CABG

26
Q

What are cardiac biomarkers?

A

Determines presence of cardiac muscle damage. Troponins, measured through a blood test are preferred because they have greater sensitivity and specificity for measuring injury to the heart muscle than other tests.

27
Q

What is ECG?

A

Electrocardiograms (ECGs) are a series of leads placed on a person’s chest that measure electrical activity associated with contraction of heart muscle.

28
Q

What are the non invasive imaging tests that could be done to detect MI?

A

Chest X-rays, stress echocardiography and myocardial perfusion imaging
Scans using radioactive contrast include SPECT CT-scans using thallium, sestamibi (MIBI scans) or tetrofosmin; or a PET scan using Fludeoxyglucose or rubidium