Myeloproliferative Disorders Flashcards
0
Q
What is polycythemia Vera?
A
Increases blood viscosity
- venous thrombosis (mesenteric vessels, portal vein)
- headaches
- blurry vision
- sob
- malaise
- pruitus
1
Q
What are they?
A
CML
Essential thrombocytosis
Polycythemia rubra Vera
Primary myelofibrosis
2
Q
Essential thrombocytosis?
A
Venous thrombosis
Erythromelalgia: warren, erythema, pain in hands/ toes
Vasomotor: headaches, light headedness, palpitations, chest pain
Haemorrhage
3
Q
How to diagnose myeloproliferative disorders? What investigations?
A
2 major or 1 major plus 2 minor criteria
Essential thrombocytosis has 4 criteria
CBE with peripheral smear
JAK2 mutation
BM biopsy
