LYMPHOMA

Question 0

Symptoms of lymphoma?

Answer 0

Enlarged painless non tender rubbery lymph nodes.

Fever, wt loss, night sweats in 25%

Lymph node mass effect can cause symptoms

Question 1

What is lymphoma? What are the types and what are their differences?

Answer 1

Cancer of the lymphocytes

Differentiated by histology

• hodgkins (reed-sternberg )
• non-hodgkins (all lymph nodes without reed-sternberg)

Question 2

Ix?

Answer 2

Lymph node excision biopsy

CBE EUC LFT LDH (increased cell turnover associated with worse turnover) ESR

Question 3

Staging of Hodgkin’s lymphoma?

Answer 3

I - confined to single lymph node
II - involvement of two or more on same side of diaphragm
III - involvement of nodes on both sides of the diaphragm
IV - spread beyond the lymph nodes e.g. Liver or bone marrow

Then A - no systemic features other than priutus
B - wt loss > 10% in 6 months, fever or night sweats

Question 4

Rx of Hodgkin’s lymphoma?

Answer 4

Chemo radiotherapy

Question 5

Emergency presentations of HL?

Answer 5

Infection
SVC obstruction -> JVP elevation
Blackouts
Facial oedema

Question 6

What is the classic distribution of prevalence?

Answer 6

Biphasic - young adults and elderly