myeloma Flashcards
1
Q
what is myeloma?
A
a b cell lymphoid malignany with abnormal plasma cells in the bone marrow
2
Q
what are signs of myeloma?
A
CRAB: calcium raised renal impairment anaemia (pancyopenia) Bone pain
3
Q
what is seen on blood film?
A
roleux
4
Q
what is a key finding in electrophoresis?
A
bence jones proteins in urine
5
Q
what does bone marrow infiltration lead to?
A
anaemia
pancytopenia: neutropenia, thrombocytopenia.
6
Q
what are lab findings?
A
raised ESR
raised CA
abormal u&ES
monoclonal band
7
Q
what is needed for diagnosis?
A
paraproteinaemia
increased plasma cells in bone marrow >10%
hypercalcaemia/ renal impairment/anaemia/ lytic bone lesions
8
Q
what is the management of myeloma?
A
incurable treat with:
thalidomide/cyclophosphamide
