Myelodysplastic subtypes

Question 1

Refractory anaemia

Answer 1

Blood
Anaemia
No blasts

BM
Erythroid dysplasia <5% blasts

Question 2

Refractory anaemia with ringed sideroblasts

Answer 2

Blood
Anaemia
No blasts

BM
Erythroid dysplasis >15% blasts
Ringed sideroblasts

Question 3

Refractory cytopaenia with multilineage dysplasia

Answer 3

Blood
Cytopaenia in >2 cell lines

BM
Dysplasia in >10% cells in >2 lines

Question 4

Refractory cytopaenia with multilineage displasia and ringed sideroblasts

Answer 4

Blood
Cytopaenia in >2 cell lines

BM
Dysplasia in >10% cells in >2 cell lines
>15% ringed sideroblasts

Question 5

Refractory anaemia with excess blasts - 1

Answer 5

Blood
Cytopaenia
<5% blasts
No auer rods

BM
Dysplasias
5-9% blasts

Question 6

Refractory anaemia with excess blasts - 2

Answer 6

Blood
Cytopaenias
5-19% blasts
Auer Rods

BM
Dysplasias
10-19% blasts
Auer rods

Question 7

MDS with 5q Deletion

Answer 7

Blood
Anaemia
Normal or increased platelets

BM
Megakaryocytes with hypoglobulated nuclei
<5% blasts

Question 8

MDS (unclassified)

Answer 8

Complex in blood and bone marrow