Lymphomas (NHL & HL)

Question 1

Follicular

Answer 1

B-cell

Presents with lymphadenopathy
Indolent but can transform to high grade

Follicular pattern of histology
T(14;18) –> bcl-2 gene

Question 2

Small lymphocytic (CLL)

Answer 2

B-cell

Indolent but can become aggressive (Richter transformation)
In nodes, or in blood

Sheet of uniform small round lymphocytes
CD5+ (normally on T-cells)

Question 3

Marginal zone (MALT)

Answer 3

B-cell

Mainly in extranodal sites

Thought to be due to chronic antigen stimulation

Indolent but can become aggressive

Can treat low grade by removing the cause (H.pylori)

Question 4

Mantle cell

Answer 4

B-cell

Lymph nodes or GI tract
Normally disseminated at presentation

Express CD5+ and cyclin D1

T(11;14)

Angular nuclei

Median survival of 3-5 years

Question 5

Burkitt’s

Answer 5

B-cell

Jaw or abdo pain in children/young adults
EBV association

Starry sky appearance on histology

c-myc translocation T(8;14)

Aggressive disease

Question 6

Diffuse large B-cell

Answer 6

Present with lymphadenopathy

Sheets of large lymphoblastic cells
P53 positive

Poor prognosis

Question 7

Peripheral T-cell

Answer 7

Lymphadenopathy and extranodal sites

Large t-cells

Aggressive

Question 8

Adult T-cell

Answer 8

Associated with HTLV-1

Question 9

Cutaneous T-cell

Answer 9

Mycosis fungoides presents with plaques on the skin

Abnormal T-cells infiltrating the dermis causing ulceration

Question 10

Anaplastic large cell

Answer 10

T-cell

Present with lymphadenopathy

Anaplastic (nuclei variable in size and shape)

T(2;5) Alk-1 protein expression

Question 11

Nodular sclerosing

Answer 11

Classical HL

Most common

Good prognosis

Question 12

Nodular Lymphocyte

Answer 12

Non-classical HL

Question 13

Treatment for HL

Answer 13

ABVD

Adriamycin
Bleomycin
Vinacristine
DTIC

Question 14

Enteropathy-associated T-cell Lymphoma

Answer 14

Associated with coeliacs