myelin damage and recovery Flashcards
1
Q
name five demyelinating diseases
A
Multiple sclerosis ADEM Transverse myelitis Optic neuritis Neuromyelitis optica
2
Q
what has research told us about what happens in MS?
A
Inflammation occurs
axonal damage occurs
demyelination occurs and remyelination occurs
3
Q
name 6 features of neuroplasticity
A
Dendritic absorption New synapses form Reorganisation of existing pathways sodium channel redistribution axonal sprouting
4
Q
what is the prevalence of neuromyelitis optica?
A
0.6 per 1000
95% recover
5
Q
what are some possible explainations as to why some people with neuromyelitic optica recover and others fail to?
A
More severe inflammation? More demyelination? More neuroaxonal loss? More damage elsewhere? Less remyelination? Less tissue reserve (i.e. less redundancy)? Less neuroplasticity?
6
Q
Optical coherence tomography (OCT) can be used to measure what?
A
axonal damage
7
Q
Gadolinium-enhanced MRI is a measure of?
A
inflammation
8
Q
Diffusion-weighted MRI of the optic radiations is used to measure?
A
tract integrity
9
Q
MRI measurements of cortical thickness and atrophy is a measure of what?
A
neuroaxonal loss
10
Q
functional MRI can be used to measure what?
A
neuroplasticity
