Mydriatics Flashcards

1
Q

Why do we use mydriatics?

A

Field of view doing techniques such as direct is small and so a midriatic can be used to increase this.

  • Enables a more thorough examination of the eye: e.g. peripheral crystalline lens, vitreous, fundus
  • Facilitates a stereo fundus examination
  • For treatment e.g. uveitis – stops iris sticking to lens
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2
Q

What are indications that we should dilate to have a view of the fundus?

A

• Patients at risk of retinal detachment:

Those with –High myopia (>-5.00 D), family history of retinal detachment , trauma

•Or if they present with any of the following symptoms:

–Unexplained vision loss/visual fields loss/disturbance

–Floaters,

  • flashes,
  • veil of vision/curtain
  • shadows
  • for screening purposes for diabetics
  • Inadequate fundus view –Lens/media opacities –Miotic pupils (less than 2mm)
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3
Q

What are the 4Ds when using a drug?

A

State the Druge, Dose , Date , Disposal

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4
Q

What should you do prior to inserting a mydriatic?

A

Explain procedure

Px consent: • Issue written information Advise effects- glare, loss of stereo vision, driving, operating machinery

Minimise risk of adverse reaction

Check for contraindications

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5
Q

How do you insert a mydriatic?

A

Ask the patient to look up:

  • Pull down lower lid
  • Instil one drop into lower conjunctival sac
  • Occlude puncta – avoids drug draining into the nasolacrimal duct thereby (i) reducing the effectiveness of the drug in the eye and (ii) increasing the likelihood of causing systemic signs and symptoms)
  • Record drug, strength, dosage, expiry date, batch number and time of instillation
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6
Q

What are contrandications for using a mydriatic?

A

Known hypersensitivity to drug e.g. px hypersensitive to tropicamide

  • Iris clip IOLs – not common
  • Narrow angles?
  • Patient with symptoms suggestive of sub-acute or chronic closed angle glaucoma (CAG)
  • Patient with diagnosed CAG
  • Px using pilocarpine for glaucoma treatment (constricts pupil which opens up drainage channels)
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7
Q

What are signs and symptoms of a closed angle glaucoma attack?

A

Sudden red eye- conjunctival hyperemia

Sudden increase in IOP

Cloudy Cornea

Fixed mid-dialted pupil

Closed angle

Blurred vision

Haloes

Headache

Painful

Vomiting/nausea

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8
Q

How can we minimise the likelihood of a closed angle glaucoma attack?

A

Take pressures before and after dilating - so we are acc aware the IOP is rising and can treat sooner.

Check anterior angles

Use a miotic drug?

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9
Q

When would we refer in regards to pressures following a mydriatic?

A

If there is a significant rise in pressures that does not fall.

If there is an asymetric rise in pressures between eyes.

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10
Q

Give four examples of mydriatics

A

Tropicamide

Cyclopentolate

Atropine

phenylephrine

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11
Q

Give examples of muscarinic mydriatics

A

Tropicamide –Most commonly used

Cyclopentolate –Rarely used as a mydriatic

Atropine –Only available to independent prescribers –Unlikely to be used as mydriatic

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12
Q

Give an example of a sympathomimetic mydriatic

A

Phenylepherine –Used more in USA

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13
Q

How does tropicamide work?

A

It is a muscarinic antagonist - it blocks acetyl choline getting to muscarinic receptors in the parasympathetic branch of the autonomic nervous system - specifically on the ciliary and sphincter muscles.

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14
Q

How does phenylephrine work?

A

In the sympathetic branch of the autonomic nervous system - it mimicks noradrenaline on alpha receptors on the dilator muscle.

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15
Q

Describe how the iris muscles work to either dilate or constrict the pupil - describing the different branches of the autonomic nervous system each muscle falls under

A
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16
Q

What effect does inhibition of the parasympathetic nervous system cause?

A

 mydriasis  cycloplegia  reduced tear secretion

17
Q

What are the two types of receptors in the sympathetic nervous system and which one does phenylephrine work on?

A

Alpha and beta receptors •Mainly alpha 1 receptors in dilator pupillae muscle

Phenylephrine is a selective alpha 1 –adrenergic receptor activator acting on the iris dilator muscle

18
Q

Describe the similarities and differences of using phenylephrine vs tropicamide to dilate

A
19
Q

What doses does tropicamide come in?

A

0.5% and 1% minims

as well as multi-dose containers

20
Q

On whom do we use 1% tropicamide and what side effect does this also cause?

A

1% sometimes used for darker irides, but will also mean also lead to an increased cycloplegic effect

21
Q

What is the guidance regarding pregnancy and dilation?

A

Pregnancy – avoid if possible, but better to use tropicamide than phenylephrine

22
Q

What is the guidance regarding tropicamide and breast feeding?

A

Women who are using Tropicamide must not breastfeed

23
Q

What are the ocular side effects of tropicamide?

A
  • Transient stinging
  • Transient blurring
  • Photophobia
  • Raised IOP?
  • After prolonged administration:

Irritation Hyperaemia Oedema Conjunctivitis

24
Q

What are the systemic side effects of using tropicamide?

A

•CNS effects Dry mouth Reported in children (blue eyes,

25
Q

What does is phenylephrine available in?

A

2.5 and 10% minims.

26
Q

Why is the use of 10% phenyl ephrine contraindicated in children and over 65s?

A

because of the increased risk of systemic toxicity.

27
Q

True or False - phenylephrine is less effective on highly pigmented eyes

A

True

28
Q

True or False- phenylephrine causes blanching of the conjunctiva – vasoconstriction of conjunctival blood vessels

A

True - and in a non mydriatic application this can be useful for determining between scleritis and episcleritis

29
Q

What are contraindications for using phenylephrine?

A

Medication- cardiovascular problems (e.g. Anti hypertensives, Tachycardia)

Medication-depression (e.g. Monoamine oxidase inhibitors, Tricyclic antidepressants)

Thyrotoxicosis

Insulin dependent diabetes

Asthma

Pregnancy/lactation-may cause transient fetal hypoxia

Use of pilocarpine–> Older px = pupil block Young px = accommodative spasm

30
Q

What are ocular side effects of phenylephrine?

A

 Transient stinging  Transient blurring  Photophobia  Lid retraction  Conjunctival allergic reaction  Punctate keratitis

31
Q

What are systemic side effects of phenylephrine?

A

■Palpitations ■Tachycardia ■Cardiac arrhythmias ■Hypertension ■Headaches

32
Q

Why do we have to be careful of drug interactions?

A

Synergistic combinations - Use of two or more substances to provide an effect greater than the sum of their separate effects

33
Q

What is a mydriasert?

A

New high tec meidcine :

Insoluble ophthalmic insert • Contains phenylephrine and tropicamide • Gradual release • Used pre-operatively and diagnostically • In adults-insert up to max. 2 hours before procedure. Remove within 30 mins of mydriasis and within 2hrs of application

34
Q

Is cyclopentolate a mydriatic?

A

yES

35
Q

What dose is cyclopentolate available in and what other effect does it have other than dilating?

A

It acts as a cycloplegic - blocking accommodation - 0.1%

36
Q

Describe homatropine

A

It is an anti-muscarinic

Mydriatic effect commences in 10-20 mins

 Maximal mydriasis 30-40 mins

 Both light and accommodative reflexes absent

 Recovery can take up to 3 day

37
Q
A