Mycosis Flashcards

1
Q

dimorphic fungi

A

two forms exist for one fungus species depending on temperature and conditions of environment

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2
Q

2 forms of fungi

A

mycelial and yeast/yeast-like

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3
Q

Dimorphic fungi capable of causing systemic infection

A
 Histoplasma capsulatum
 Blastomyces dermatitidis
 Coccidioides immitis
 Paracoccidioides brasiliensis
 Sporothrix schenckii
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4
Q

Histoplasma capsulatum

A

-Associate with Bat guano (Spelunker) and bird
droppings
-Fungal Culture incubated at 30˚ C

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5
Q

Histoplasmosis Disease

A

Reactivation disease can occur in elderly and
immunosuppressed (AIDS is a good example)
 Bone marrow exam is useful in diagnosing disseminated
infections
 Mucocutaneous lesions are common
and a site of dissemination

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6
Q

yeast of Histoplasma capsulatum

A

prefer to
be intracellular and inhabit Macrophages.
Yeast are small 2 – 4 um, regular in size, and
oval to round. Yeast do not have a capsule,
this is just a staining artifact.

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7
Q

Histoplasmosis rapid diagnosis

A

Antigen detection in urine
 Most useful for disseminated infection and chronic
pulmonary disease
 Antigen is detectable in >=85% of these infections
 Good for immune suppressed patients that do not
produce a detectable antibody response

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