MYCOLOGY (Systemic Mycoses) Flashcards
Southeast Asia
What systemic mycosis?
Talaromycosis (Penicilliosis)
Central & South America
What systemic mycosis?
Paracoccidioidomycosis
Southwestern US, Mexico
What systemic mycosis?
Coccidioidomycosis
Mississippi & Ohio River valleys
What systemic mycosis?
Histoplasmosis
Mississippi & Ohio River basins, St. Lawrence River
What systemic mycosis?
Blastomycosis
What systemic mycosis?
Yeast-like cells inside macrophages, red diffusible pigment in culture
Talaromycosis (Penicilliosis)
What systemic mycosis?
Yeast with “pilot wheel” appearance
Paracoccidioidomycosis
What systemic mycosis?
Spherules containing endospores
Coccidioidomycosis
What systemic mycosis?
Small intracellular yeast (2-5 µm) in macrophages
Histoplasmosis
What systemic mycosis?
Broad-based budding yeast, DNA probe confirmation
Blastomycosis
Also known as Gilchrist disease, North American blastomycosis, Chicago disease.
Blastomycosis
Affects primarily middle-aged men due to occupational/recreational exposure to soil.
Blastomycosis
Often asymptomatic; primary infections may cause flu-like symptoms.
Progressive pulmonary disease presents with:
Cough, weight loss, chest pain, fever.
May progress to ulcerative skin and bone lesions.
Blastomycosis
causative agent of Blastomycosis
Blastomyces dermatitidis
Blood agar, 37 degree celsius
Blastomyces dermatitidis
Pines medium,
Glucose-cysteine blood,
BHI-blood,
37 degree celsius
Histoplasma capsulatum
BHI-blood, 37 degree celsius
Paracoccidioides brasiliensis
MOT: Inhalation of arthroconidia
what causative agent?
Coccidioides immitis
MOT: Inhalation of microconidia (bird/bat guano)
what causative agent?
Histoplasma capsulatum
Mariner’s wheel yeast cells
Paracoccidioides brasiliensis
Valley fever
Coccidioides immitis
erythema nodosum
Coccidioides immitis
Pulmonary calcifications, chronic lung disease
Histoplasma capsulatum
Ulcerative mucosal lesions, lymphadenopathy, adrenal involvement
Paracoccidioides brasiliensis
Disseminated disease in AIDS patients, cutaneous lesions
Penicillium marneffei
Most virulent of all human mycotic agents.
Coccidioides immitis
Erythema nodosum (desert bumps),
erythema multiforme (valley fever),
arthritis (desert rheumatism)
Allergic manifestations of what fungi
Coccidioides immitis
Disseminated disease (1% of cases): Higher risk in Filipinos, Black individuals, and pregnant women. Commonly affects the meninges.
Coccidioides immitis
Endemic areas: Lower Sonoran life zone (arid regions).
Coccidioides immitis
Initial colonies: White to gray, moist, glabrous → Develop aerial mycelium → Mature colonies tan, brown, or lavender.
Coccidioides immitis
Common in immunocompetent individuals, residual calcifications in lungs, liver, spleen.
Histoplasma capsulatum
Histoplasma capsulatum
Chronic pulmonary histoplasmosis: Common in ___ patients.
COPD
Endemic areas: Ohio, Missouri, Mississippi River valleys.
Histoplasma capsulatum
Reservoir: Soil with high nitrogen content (bat/bird guano).
Histoplasma capsulatum
Resembles Candida glabrata (differentiated via FA techniques or culture).
Histoplasma capsulatum
Histoplasma capsulatum
Resembles Candida glabrata (differentiated via ___ techniques or culture).
FA
Serology:
EIA: Antigen detection from blood, CSF, urine.
Antibody tests: Complement fixation, immunodiffusion, latex agglutination.
Most useful: Rising titers in complement fixation & immunodiffusion.
Histoplasma capsulatum
22°C: White to brownish mold.
Histoplasma capsulatum
H. capsulatum var. duboisii (Central Africa) → ___
H. capsulatum var. farciminosum → ___
H. capsulatum var. duboisii (Central Africa) → Skin & bone disease.
H. capsulatum var. farciminosum → Epizootic lymphangitis in horses/mules.
Ulcerative granulomatous lesions (buccal, nasal, GI mucosa).
Paracoccidioides brasiliensis
Other manifestations: Mediastinitis, pericarditis, mucocutaneous lesions.
Histoplasma capsulatum
South American blastomycosis
Paracoccidioidomycosis
Brazilian blastomycosis
Paracoccidioidomycosis
Lutz-Splendore-Almeida disease
Paracoccidioidomycosis
Gilchrist disease
Blastomycosis
Chicago disease
Blastomycosis
Endemic in: Central & South America (humid, high-rainfall, acidic soil conditions).
Paracoccidioides brasiliensis
Mickey Mouse cap appearance (fewer buds).
Paracoccidioides brasiliensis
22°C: Mold phase → Glabrous to leathery, wrinkled, pink to brown colonies.
Paracoccidioides brasiliensis
Only dimorphic Penicillium spp.
Penicillium marneffei
Paracoccidioides brasiliensis
37°C (____ agar): Rapid conversion to yeast phase.
BHI blood
Opportunistic pathogen: Common in immunocompromised patients (AIDS, hematologic malignancies) in Southeast Asia.
Penicillium marneffei
Resembles Histoplasma capsulatum.
Penicillium marneffei
Mold phase → Green aerial hyphae, reddish-brown vegetative hyphae.
Penicillium marneffei
desert bumps also called ___
Erythema nodosum
valley fever is also called ___
erythema multiforme
Produces red diffusible pigment.
Penicillium marneffei
Antigen detection for Histoplasma capsulatum uses what specimen
blood, CSF, urine
Natural reservoir: Soil; also infects dogs and horses.
Blastomyces dermatitidis (Blastomycosis)
North American blastomycosis
Blastomycosis