Mycology - Introduction Flashcards

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1
Q

What are the key descriptors of a fungus?

A
  • Eukaryotic
  • Heterotrophic
  • Devoid of chlorophyll
  • Obtains nutrients by absorption
  • Reproduces by spores
  • Multicellular, except yeasts
  • Contain cell walls
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2
Q

Define heterotroph.

A

A heterotroph is an organism that needs to feed on other organisms in order to make their own energy-containing organic molecules. Includes:

  • Saprophytes
  • Parasites
  • Symbionts
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3
Q

Define saprophyte.

A

An organism that obtains food from decaying matter.

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4
Q

What is contained in the fungal cell wall?

A
  • Chitin microfibrils (β(1-4)-linked polymer of N-acetylglucosamine)
  • β-linked glucans
  • Glycoprotein
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5
Q

What type of sterol is contained in the plasma membrane of fungi?

A

Ergosterol

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6
Q

What are the different morphologies of fungi?

A
  1. Moulds (Filamentous)
  2. Yeasts
  3. Yeast-like (yeasts producing pseudohyphae)
  4. Dimorphic
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7
Q

What are the characteristics of moulds?

A
  • Filamentous
  • Multicellular
  • Generally found in nature
  • Have hyphae
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8
Q

What are hyphae?

A

Cylindrcal, branching filaments composed of a tubular cell wall filled with cytoplasm and organelles. Usually 2-10 μm in diameter.

Can be non-septate coenocytic, or septate hypha.

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9
Q

What are the characteristics of yeasts?

A
  • Mostly classified with Ascomycetes
  • Generally spherical, oval, or cylindrical
  • Common form found in tissue lesions
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10
Q

Under what conditions do dimorphic fungi change?

A

Found as moulds at lower temperatures/room temperature, and change to yeasts at body temperature (37ºC).

e.g. Histoplasma

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11
Q

How do filamentous fungi asexually reproduce?

A

Conidiophores on the ends of hyphae produce conidia (spores) that can germinate and become new hyphae.

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12
Q

How do yeasts asexually reproduce?

A

Budding

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13
Q

What are the four classifications (phylums) of fungi based on sexual reproduction?

A
  1. Chytridiomycota (flagellated, mostly aquatic)
  2. Zygomycota (Rhizopus decomposes strawberries)
  3. Ascomycota (yeasts, molds, morels, truffles)
  4. Basidiomycota (Cub-fungus)
  5. Deutromycetes (no known sexual spores)
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14
Q

What are the main steps of sexual reproduction of fungi?

A
  1. Two different mating types (+/-) come into contact (n)
  2. They undergo plasmogamy (n+n)
  3. Produces a dikaryotic/heterokaryotic hypha(e)/mycelium (n+n)
  4. They undergo karyogamy (n+n→2n)
  5. Meiosis to form haploid nuclei (n)
  6. Mitosis to form spores
  7. Dispersal
  8. Germination
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15
Q

What are the types of diseases that pathogenic fungi cause?

A
  1. Superficial (dead skin)
  2. Cutaneous (epidermis, hair, nails)
  3. Sucutaneous (dermis, subcutis)
  4. Systemic (internal organs)
  5. Opportunistic (internal organs)
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16
Q

What are the main virulence factors for pathogenic fungi?

A
  1. Adherence (surface proteins)
  2. Invasion (conidia shift to yeast, yeast shift to hyphae, hyphal extension, digestive enzymes)
  3. Resist phagocytosis (capsule: thick/polysaccharide)
  4. Tissue injury (enzyme production, toxin production)
  5. Chronic inflammation