Mycology Flashcards
what are the two categories of fungal agents?
fungal pathogens and opportunistic fungi
What factors increase the risk of opportunistic mycoses?
invasive medical procedures and medical therapies
what is the most common type of mycosis?
fungal infections
what are the three categories of clinical manifestation of fungal diseases?
fungal infections
toxicoses
allergies
what causes toxicoses?
acquired through ingestion
(when poisonous mushrooms are eaten)
What is used to culture and grow fungi?
sabouraud dextrose agar
Why do fungi often resist T cell-mediated immune responses?
fungi are biochemically similar to human cells and can harm human cells
what is the gold standard of antifungals?
amphotericin B
what is the two-step treatment for opportunistic infection?
high dose: treatment to reduce pathogens
low dose: maintenance therapy
How is Nystatin used in anti fungal therapies?
topically
What do -azole drugs target in fungal cells?
target ergosterol (biosynthetic enzyme)
What are some fungi against which scientists have developed vaccines?
Candida
coccidiosis
blastomycosis
What four pathogenic fungi cause systemic infections?
Blastomyces
Coccidioides
Histoplasma
Paracoccidioides
What is the division of these fungi Blastomyces
Coccidioides, Histoplasma, Paracoccidioides?
ascomycota
How are ascomycota infections aquired?
inhalation of spores
starts as pulmonary infection > to blood
What is unquie about ascomycota fungi?
dimorphic
have different manifestation in environment and in host
what is the most fungal infection affecting humans?
Histoplasmosis
Where is Histoplasmosis found?
in soils containing high nitrogen levels
what are the clinical manifestations of Histoplasmosis?
chronic pulmonary
ocular
chronic cutaneous
systemic
What is the causative agent of Histoplasmosis?
Histoplasma capsulatum
What is the causative agent of Blastomycosis?
Blastomyces dermatitidis
Where is Blastomycosis found?
in soils rich in organic matter
what is the most common manifestation of Blastomycosis?
pulmonary Blastomycosis
What pathogenic fungi is also known as “valley fever”?
Coccidioidomycosis