Mycobacterium Tuberculosis Flashcards

1
Q

¿De que otra forma se le conoce?

A

Bacilos de Koch

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2
Q

Características

A

Bacilo BAAR+
Aerobio estricto
Incapaz de multiplicarse fuera del ser humano
Altamente resistente a factores mecánicos y químicos adversos

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3
Q

Periodo de incubación

A

2-4 semanas

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4
Q

Transmisión

A

Gotas de Fluge: Aerosoles de personas infectadas (estornudar, toser, hablar)
Oral - Ingerir leche de vaca contaminada
Contacto directo

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5
Q

Dosis infectiva

A

10 bacilos por inhalación

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6
Q

Epidemiología

A

África

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7
Q

Factores de virulencia

A

Pared celular
Ags proteicos
Liberan enzimas permiten proliferación intracelular

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8
Q

Complejo común BGC85

A

Median la adhesión e invasión de los bacilos

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9
Q

Antígeno 10kDa

A

Proliferación de los Lc > relevante para la formación de los granulomas

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10
Q

Factor cordón

A

Inhibe la proliferación de PMN y favorece la formación de granuloma crónico

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11
Q

Lípidos en la pared celular

A

Impermeabilidad de agentes anti-microbianos
Resistencia a compuestos ácidos y alcalinos
Resistencia a lisis por el complemento
Aumenta la supervivencia dentro del MO

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12
Q

Glicolípido de unión a manosa LAM

A

Favorece la adherencia a los MO y disminuye los mecanismos citotóxicos

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13
Q

Complejo antigénico 85

A

Unión a fibronectina

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14
Q

¿Dónde reside?

A

Compartimientos ligeramente ácidos

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