Myasthenia Gravis Flashcards
1
Q
Clinical features of myasthenia gravis
A
- Midline CN dysfunction
- Proximal weakness w/fluctuations (esp neck flexors)
- Ocular often involved
2
Q
Who is MC affected by myasthenia gravis?
A
30 yo females
50 yo males
3
Q
Physical exam findings in myasthenia gravis
A
- Ptosis, diplopia
- Dysphagia, arthria
- NORMAL reflexes
- NORMAL sensory, bowel, bladder, cognition
4
Q
How can myasthenia gravis be diagnosed?
A
- ACh receptor binding antibody positive
- Tensilon test (in hospital w/EKG)
- Nerve conduction repetitive stimulation test (3 sites if tolerated)
- Single fiber EMG
5
Q
What neuro condition is a/w thymoma?
A
Myasthenia gravis (50% pts have thymic hyperplasia)
6
Q
Treatment of myasathenia gravis
A
Symptomatic
- Mestinon
- Prednisone
- IVIG
7
Q
How to ddx ALS vs. myasthenia gravis
A
- ALS NEVER has ocular motor deficits
- ALS has diffuse distal atrophy/fasciculations
- ALS has hyperreflexes
8
Q
How to ddx MG vs. Guillain Barre
A
GBS will have some sensory deficits and reflexes drop early
