Myasthenia gravis Flashcards
Describe three signs and symptoms of myasthenia gravis
Muscular fatigue
- extra-ocular
- bulbar (voice deteriorates)
- face- myasthenic snarl
- Neck- head droop
- Limb
What is the pattern of limb weakness in myasthenia gravis?
asymetrical
List two factors that exacerbate myasthenia gravis
pregnancy, infection, drugs, emotions
Investigations for myasthenia gravis/muscle fatiguability?
anti-AchR Abs
Resp function tests
TFTs
Tensilon test- if improvement within 1 min then positive
What is the treatment for myasthenia gravis?
symptomatic control- anticholinesterase e.g. pyridostigmine
Immunosuppression- steroids + azathioprine, methotrexate
Which surgical intervention can be used to manage myasthenia gravis?
thymectomy- removal of thymus gland (produces WBC), ressection associated with myasthenia remission
What is a major complication of myasthenia gravis?
myasthenic crisis- weakness of resp muscles
What should be monitored during myasthenic crisis?
FVC
Which condition is commonly associated with myasthenia gravis?
diabetes
