Mutations Flashcards by Eric Kutscher

Q

8;21

A

AML

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Q

15;17

A

APL

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Q

12;21

A

children’s ALL

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Q

9;22

A

PH+, either CML or B-all adult

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Q

CD5+

A

Increased in CLL

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Q

TRAP

A

Positive with hair cell leukemia

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Q

Rash Leukemia

A

Adult T Cell Leukemia

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Q

617 exon 4

A

PV

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Q

Pruritis

A

PV

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Q

LAP-

A

CML

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Q

CARL+

A

ET or primary myelofibrosis

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Q

CD30+

A

Hodgkins Lymphoma

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Q

ABVD risk

A

Coronary artery disease

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Q

Hodgkins staging

A

Ann Arbor

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Q

Lacunar cells

A

Nodular sclerosing

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Q

14;18

A

BRC2 in Follicular NHL

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Q

11;14

A

Cylcin D in Mantle NHL

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Q

8;14

A

C-Myc in Burkitt’s

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Q

Starry Sky

A

Burkitt’s

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Q

Sheets of large B cells

A

DLBCL

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Q

IL6

A

Multiple myeloma

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Q

RANK

A

Multiple Myeloma

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Q

IgM

A

Waldenstrom’s

Q

14q32

A

Multiple Myeloma

Q

4;14

A

Multiple Myeloma, high risk

Q

Birbeck Granule

A

Tennis racket, Langerhan’s Cells

Q

CD1A+ and S100+

A

Langerhan’s Cells

Q

drug causing hand-foot syndrome

A

Capecitabine, pyrimidine analog

Q

drug causing Hemorrhagic Cystitis

A

Cyclophosphamade, DNA Alkylator

Q

drug causing Cardiotoxicity

A

Doxorubicin

Q

drug causing Pulmonary fibrosis

A

Bleomycin

Q

drug causing early menopause-like symptoms

A

Tamoxifen

Q

drug causing clotting

A

Bevacizumab

Q

anti-CD30 drug

A

Brentuximab

Q

CTLA-4 function

A

turn off T cell in “effector” stage

Q

B7 paired with

A

CD28

Q

PD1/PDL1

A

Turns off T cell

Q

CTLA4 blocker name

A

ipilimumab

Q

drug causing hepatitis

A

ipilimumab (anti CTLA4)

Q

PD1 blocker name

A

nivolumab

Q

drug causing arthralgias

A

nivolumab (anti-PD1)

Q

RAR-a

A

APL

Q

Type M3 AML

A

APL

Q

CD11+

A

Hairy Cell Leukemia

Q

CD10+

A

Follicular NHL

Q

G1 to S phase

A

Due to Cylcin D mutation in Mantle NHL

Q

Richter’s Syndrome

A

SLL

Q

3q27

A

DLBCL

Q

Amyloidosis (primary)

A

Multiple Myeloma

Q

Multiple myeloma tx

A

Thalidimide and bortezomib

Q

Methyltrexate target

A

DHFR making TS

Q

HER2 drug

A

trastuzimab

Q

EGFR (2 drugs)

A

Erlotinib

Certuximab

Q

VEGF drug

A

bevicizumab

Q

BRAF drug

A

verumafenib

Q

Anti-CD30

A

Brentuximab

Q

CD3+

A

Langerhan’s (Letter-Siwe)