Lymphomas

Question 1

Clonality

Answer 1

identical cells derived from the same cell, including tumor cell clones and subclones in tumor heterogeneity

Question 2

Cancer Stem Cells

Answer 2

cancer cells that give rise to all cell types found in a particular cancer sample. Tumorgenic with self-renewal capabilities

Question 3

Dominant mutations

Answer 3

mutations in prot-oncogenes are usually dominant

Question 4

Maturation arrest

Answer 4

human myeloid leukemias provide models of maturation arrest and differentiation therapy of cancer. The genetic lesions of leukemia result in a block of differentation that allows myeloid leukemias to continue to proliferate

Question 5

Genomic instability

Answer 5

high frequency of mutations within the genome of a cellular lineage

Question 6

lymphomagenesis

Answer 6

AID (activation-induced cytidine deaminase) and double strand breaks

Question 7

Philadelphia body

Answer 7

missing part of 22 etc