Musculoskeletal System Flashcards
osteoporosis - definition and risk factors
loss of bone matrix and mineral - leads to fx w/ little trauma
Primary: post menopausal (due to loss of estrogen) and senile (calcium deficiency and dec. vit. D intake)
Secondary: chronic corticosteroid use, hyper and hypo thyroids, hyperparathyroidism, DM, Cushing’s dz
RFs:
- Caucasian or Asian
- small, thin
- smoking hx, ETOH
- low calcium intake
- corticosteroid use
osteoporosis - dx
DEXA scan (get T score) - screening begins at 65 (F) and 70 (M) unless have risk factors
normal: T score w/in 1 SD of young adult reference
osteopenia: 1-2.4 SD below reference
osteoporosis: 2.5 or more SD below reference
osteoporosis - most common fx sites
vertebral bodies
- most common
hip, pelvis, distal radius
osteoporosis - lifestyle changes
weight-bearing exercise intake of Ca++ and it D use walk or cane for balance balance exercise stop smoking and ETOH healthy diet
osteoporosis - medications
calcium and vit. D
- Ca++: 1000 mg/day
- Vit D: 800-2000 IU daily
bisphosphanates
- e.g. fosamax, boniva
- take in am, drink w/ H2O, avoid eating for 30 min (avoid esophagitis)
- only take for 2-3 yrs
denosumab: inhibits maturation of bone absorbing cells
- dosed Q 6 mo
teriparatide: parathyroid hormone analog
- good but expensive
- only use for 2 yrs due to risk of osteosarcoma
compartment syndrome - definition
increased pressure in area with limited space
- something surrounded by facia
- compromises circulation and tissue fx
compartment syndrome - causes
bleeding or edema in closed compartment
- usually trauma or crush injury
compartment syndrome - sxs and tx
6 P's Pain (severe and out of proportion) Paresthesia Paralysis Pallor Pulselessness Poikilothermic (cant regulate core temp)
tx: urgent fasciotomy
osteoarthritis - definition and sxs
idiopathic, non-inflammatory arthritis
Sxs:
- jt stiffness in am (relieved w/ activity)
- pain w/ wt bearing
- crepitus, jt swelling, dec. ROM
- Heberden’s (DIP) nodes - common
- Bouchard’s (PIP) nodes
osteoarthritis - nodes
Heberden’s (DIP) nodes
- common
Bouchard’s (PIP) nodes
- less common
osteoarthritis - dx and tx
Dx: x-ray - narrow jt space, osteophytes, bone cysts
Tx: acetaminophen, NSAIDs, topical diclofenac, steroid injections, visco-supplementation
- surgery if QOL is diminished
acute osteomyelitis - definition and sxs
bacterial spread to bone via blood
- S. aureus most common
- < 2 weeks
- affects long bones of children and spine of older adults
Sxs:
- fever, chills, malaise, irritability
- local warmth and swelling
- refusal to use affected limb (kids)
acute osteomyelitis - Dx and Tx
Dx:
- inc. WBC, ESR, CRP, + blood cx
- bone biopsy to confirm bacteria
- bone scan and MRI help early
Tx:
- IV ABX 4-6 wks, then oral 6-8 wks (oxacillin/cefazolon/Vanco if MRSA)
- surgical debridement if no improvement or if spine involved
chronic osteomyelitis - definition and sxs
untreated blood infection or exogenous/untreated trauma or infection (e.g. DM ulcer now infecting bone)
- > 2 weeks
- bacterial spread to bone via blood
Sxs:
- mild fever, mild inc. in ESR and CRP
- inflammation or cellulitis
- persistent drainage, sequestrum or dead bone or walled-off pus
chronic osteomyelitis - Dx and Tx
Dx:
- x-ray shows bone destruction
- may confirm with MRI
Tx: long-term IV ABX (bacterial specific - oxacillin/Vanco most common)
- surgical I&D, possible amputation
septic arthritis - definition and sxs
bacterial spread from blood to joint
- kids: N. gonorrhea
- older, IV drug use, DM, prosthetic jt: S. aureus
sxs:
- fever, jt swelling, redness, painful/limited ROM
- N. gonorrhea - lesions on palms and soles of feet
septic arthritis - Dx and Tx
Dx:
- inc. WBC, ESR, CRP
- confirm with + blood or joint cx
- jt fluid: WBC, polys, dec. glucose (bacteria eat)
Tx:
- rest, ice, elevation
- arthroscopic I&D
- IV ABX 4-6 wks (ceftriaxone/vanco)
ganglion cysts - definition, sxs, dx, tx
collection of synovial fluid
- most benign tumor of wrist
sxs: painless, fluid filled mass usually at wrist
Dx: clinical
Tx: wrist splinting, aspiration, surgical excision
bone tumors - benign vs. malignant (x-ray findings)
benign:
- well-defined margins
- sclerotic band around tumor
- slow growing
malignant:
- painful
- palpable mass
- permeative lesion w/ lytic destruction
- poor margins with suggest rapid growth
bone cysts - definition, sxs, dx, tx
cavity in bone filled w/something besides bone (usually fluid or blood)
- found in 5-20 y/o
sxs: asymptomatic until pathological fx
dx: found on routine x-ray, confirm w/ biopsy
tx: aspirate/inject w/ steroid or bone marrow to encourage growth
osteoid osteoma
most common benign bone tumor
- usually in spine or long bones
- M>F, young adults
sxs: aching, night pain relieved w/ NSAIDS (since prostaglandins in tumor)
dx: x-rays
tx: symptomatic or surgical removal if bothering
osteosarcoma - definition and sxs
most common primary malignant tumor (except MM)
- 15-25 y/o (M>F)
- most around knee
- metaphyseal (ball of bone)
NOTE: retinoblastoma assoc w/ 500x risk!!
sxs:
- persistent night pain (wakes) and swelling
- palpable mass
- no known trauma
osteosarcoma - Dx and Tx
Dx:
- x-ray shows destruction (SUN RAY or SUNBURST appearance)
- bone or soft tissue biopsy
- alk phos inc. 2-3 x
Tx:
- chemotherapy and surgical resection: 70% 5-yr survival rate
Ewings sarcoma - definition and sxs
malignant bone tumor
- most often in pelvis, distal femur, proximal tibia
- involved diaphysis of bone (shaft)
- 10-20 y/o, M>F
sxs: pain, palpable mass, fever, elevated ESR and WBC, increased LDH
Ewings sarcoma - Dx and Tx
Dx:
- x-ray shows lytic, destructive lesion
- ONION SKIN appearance
Tx:
- surgical resection, chemo, radiation
- 60-70% survival rate w/o METS
fibromyalgia - demographic and sxs
age 20-50, F>M, associated w/ hypothyroidism, RA (in women) or OSA (in men)
- dx of exclusion
sxs:
- MSK pain around neck, shoulders, low back, hip
- fatigue, numbness, H/As
- depression, sleep problems
PE: None, except trigger pt pain
fibromyalgia - tx
patient education:
- it is a chronic dz, but does not progress
moderate exercise, CBT
Meds:
TCAs, SSRIs/SNRIs, pregabalin and gabapentin, acetaminophen (better then NSAIDS)
- trigger pt injections
gout - etiology and population at risk
caused by under excretion or over production of uric acid
- 90% male
- usually in small joints (big toe)
At risk:
- thiazide or loop diuretic, beta-blockers, ACE-I, ARBs
- obesity
- high ETOH intake
- high purine diet
gout - sxs and dx
sxs:
- fever, sudden onset on monoarticular jt swelling
- exquisite PAIN, warm and red skin
- may develop TOPHI (uric-acid deposits) on ears, hands, elbows, and feet if not treated
dx:
- uric acid > 7.5, inc. WBC
- synovial fluid: + sodium urate crystals, negatively birefringent and needle-like
gout - tx (acute and chronic)
acute:
- NSAIDS, corticosteroids (must r/o septic arthritis), colchicine
Chronic:
- undersecretion: probenicid
- overproduction: ALLOPURINOL
chronic management: weight loss, increase dairy, limit ETOH, red meat, sardines, lentils, oatmeal, spinach, mushrooms, and drugs that cause gout
pseudogout - definition, sxs, dx, tx
recurrent arthritis in large joints (knee, wrist)
- M=F, > 50 y/o
- aka CPPD (calcium pyrophosphate dihydrate)
sxs: same as gout (fever, pain, swelling and warm)
dx:
- normal uric acid levels
- synovial fluid shows RHOMBOID shaped crystals that are POSITIVELY birefringent
tx:
- acute: NSAIDS, corticosteroids (must r/o septic arthritis)
- chronic: colchicine or NSAIDS (w/ GI protection)
juvenile idiopathic / rheumatoid arthritis - demographic
F>M, peaks 1-3 yr and 8-12 yr
if RF + (15%), more likely to progress to adult RA
juvenile idiopathic / rheumatoid arthritis - 3 types
systemic (Still’s disease)
- fever, salmon-colored rash, lymphadenopathy, carditis, splenomegaly, arthritis
polyarticular
- low-grade fever, arthritis 5 or more joints
oligo/pauciarticular
- synovitis in 1-4 joints, NO systemic sxs
- inc. incidence of iridocyclitis/anterior uveitis (F/U w/ opthamologist)
juvenile idiopathic / rheumatoid arthritis - dx
wt. loss, myalgias, fatigue, lymphadenopathy
intermittent fevers, morning stiffness, salmon colored rash
ESR and CRP elevated
- 10% + ANA, RF usually neg, anti-CCP may be + (high specificity for JRA)
juvenile idiopathic / rheumatoid arthritis - classification criteria
age < 16 y/o
arthritis in 1 or more joints
sxs > 6 weeks
other causes excluded
NOTE: dx of exclusion
juvenile idiopathic / rheumatoid arthritis - tx
NSAIDS: 1st line
DMARS: if no response to NSAIDS but long-term effects unknown
75% resolve w/o serious disability
- RF + have highest risk of persistent, severe dz
polyarteritis nodosa - definition and sxs
necrotizing arteritis of medium-sized vessels
- rare, 50-70 y/o
- 5% of cases cause by HEPATITIS B
- causes aneurysms of vessels
sxs:
- fever, malaise, wt loss
- extremity pain, foot drop, livid reticular (lacy red rash), nodules, digital gangrene (fingers and toes), abdominal pain N/V
polyarteritis nodosa - dx and tx
Dx:
- tissue biopsy or angiogram
- HTN if blood supply to kidneys is compromised
Tx:
- high dose corticosteroids
- also treat Hep B if they have it
Note: survival only 10% if not treated
polymyositis / dermatomyositis - definition and sxs
systemic disorder of unknown cause
- peaks in 5-6th decade, F>M, blacks > whites
- associated with malignancy in up to 20%
sxs:
- progressive neck and proximal muscle weakness or UE and LE
- 20% have dysphagia (due to weakness of neck)
- fever, wt. loss, fatigue
Reddish-purple maculopapular rash
- eyelids: heliotroph rash (red)
- knuckles: gottron papules (red, scaly rash)
polymyositis / dermatomyositis - dx and tx
Dx:
- muscle biopsy (inc. CPK, aldolase, LDH)
- serum marker: anti-JO 1 antibodies
Tx:
- corticosteroids (oral for muscle dx and topical for skin dz)
- screen for malignancies
reactive arthritis (Reiter syndrome) - definition and demographic
tetrad: conjunctivitis, urethritis, aseptic arthritis, and oral lesions
- occurs after gastroenteritis or STI (M:F is 9:1 if STI)
reactive arthritis (Reiter syndrome) - sxs, dx, tx
sxs:
-fever, arthritis (knee/ankle), urethral d/c, conjunctivitis, mucocutaneous lesions
dx:
- anemia, leukocytosis, thrombocytosis
- inc. ESR, HLA-B27 + (50-80%)
- x-ray: joint destruction
tx: NSAIDS, PT
- less likely to develop in future if original infection treated with ABX