Musculoskeletal disorders Flashcards
DJD Description
Degeneration of articular cartilage with hypertrophy of subchondral bone and joint capsule of WB joints
• Decreased joint space
• Decreased height of articular cartilage
• Presence of osteophytes
DJD Treatment
Corticosteriods
NSAIDS
Glucocorticoids (injected)
Common Intervention
DJD Dx
Plane images Lab tests (rule out RA)
Ankylosing Spondylitis: Description
Progressive inflammatory disorder of unkown etiology that intially affects axial skeleton.
Initial onset (mid-LBP approx 3 months) before 40
• Mid and low back pain
• Morning stiffness
• Sacroiliitis
Results in kyphotic deformity or cervical and thoracic spine with flattening of lumbar
Affects men 3x >women
Ankylosing Spondylitis: Tx
NSAIDs Corticosteroids Cytotoxic drugs Tumor Necrosis Inhibitors Common intervention
Ankylosing Spondylitis: Dx
HLA-B27 antigen
Gout: Description
Genetic disorder of purine metabolism, characterized by elevated serum uric acis levels; which may form crystals and deposit into peripheral joints etc
Most frequently at the knee and great toe
Gout: Tx
NSAIDs Cox II inhibitors Colchicine Corticosteriods Adrenoacorticotropic hormone ACTH Allopurinol Probenecid Sulfinpyrazone
Patient education
Early identification
Gout: Dx
Lab tests to identify monosodium urate cyrstals in synovial fluid and/or connective tissue samples
Psoariatic Arthritis: Description
Chronic erosive inflammatory disorder of unknown etiology associated with psoriasis
Erosive degeneration usually occurs in joints of digits and axial skeleton
Male = Female
Psoariatic Arthritis: Tx
Acetominophen NSAIDs Anti rheumatics (DMARDs) Biological response modifiers (BRMs) (Enbrel)
Psoariatic Arthritis: Dx
Rule out RA
Rheumatoid Arthritis: Description
Chronic systemic disorder of unknown etiology involving a symmetrical pattern of dysfunction of synovial tissues and articular cartilage of joints in hands, wrists, elbows, shoulders, knees, ankles and feet
MCP = pannus, ulnar drift, volar sublux
PIP = swan neck, bouteniere, bouchards nodes
Women 2-3x > men
Juvenile RA onset before 16 with complete remission in 75% of children
Rheumatoid Arthritis: Tx
Gold compounds Antirheumatics NSAIDs Immunosuppressive agents Corticosteroids Common Intervention
Rheumatoid Arthritis: Dx
Plain films (symetrical)
High white blood cell count and erythrocyte sedimentation rate
Elevated hemoglobin and hematocrit levels
Osteoporosis: Description
Metabolic disease that depletes bone mineral density/mass, predisposing individual to fracture.
Affects women 10x > than men
Common fracture sites include: lumbar, femoral neck, proximal humerus, proximal tibia, pelvis and distal radius
*primary or post-menopausal osteoporosis is directly related to decrease in estrogen production
*senile osteoporosis occurs from a decrease in bone activity
Osteoporosis: Tx
Calcium Vitamin D Estrogen Calcitonin Biophosphonates Common intervention
Osteoporosis: Dx
CT scan
Single/Dual photon absorptiometry
Osteomalacia: Description
Characterized by decalcification of bones due to vitamin D deficiency Symptoms: • Severe pain • Fractures • Weakness • Deformities
Osteomalacia: Tx
Calcium
Vitamin D
Calciferol (VD injections)
common intervention
Osteomalacia: Dx
Plain films
Lab tests
Bone scan
Bone biopsy
Osteomyelitis: Description
An inflammatory response within bone caused by an infection (usually staphylococcus aureus)
More common in children and immunosuppressed adults, males > females
Osteomyelitis: Tx
Antibiotics
Nutrition
Surgery (if needed)
Osteomyelitis: Dx
Lab tets
Bone biopsy
Osteogenesis Imperfecta: Description
Inferited disorder transmitted by an autosomal dominant gene
Characterized by abnormal collagen synthesis, leading to an imbalance between bone deposition and reabsorption.
Cortical and cancellous bones become very thin, leading to fx/deformity of WB bones
Osteogenesis Imperfecta: Tx
Calcium Vitamin D Estrogen Calcitonin Biophosphonates Common Intervention