Muscles and Organs Flashcards
L15 L16 L17 L18 L21
What are some smooth muscle containing organs?
Blood vessels (contorls blood flow and pressure)
GI tract (controls mixing and propulsion of GI contents)
Bladder (Controls uninattion)
Uterus (Responisble for labour)
Respiratory system (Controls diameter of airways)
Corpus cavernosum and Vas deferens (controls ejactuation and erections)
Iris (Controls pupil diameter)
What drugs affect the smooth muscles of the cardiovasulcar system?
Vasodilators
What drugs affect the smooth muscles of the GI system?
Spasmolytics (anti-muscarinic)
What drugs affect the smooth muscles of the Genitourinary system?
Anti-muscarinic and Beta3 agonists to treat lower urinary tract symptoms
PDE inhibitors for erectile dysfunction
What drugs affect the smooth muscles of the respiratory system?
Bronchodilators
What are the mechanisms for drugs affecting smooth muscle function?
Drugs block or stimulate receptors
or
Drugs act on smooth muscle cell signal transduction
How are smooth muscles stimulated?
Calmodulin can bind to up to 4 Ca2+ ions. When [Ca2+] in smooth muscle increases, Ca2+ binds to calmodulin, which then binds to myosin light chain kinase to form an active complex.
The complex phosphorylated myosin, which automatically begins the cross bridge cycle to cause contraction.
What relaxes smooth muscles?
Myosin phosphatase activation dephosphorylates myosin which because contraction to cease.
What does rho kinase do to smooth muscle?
Inhibits myosin phosphatase which causes Ca2+ sensitisation to promote contraction of smooth muscle
What does NO do to smooth muscles?
Actuvates myosin phosphatase to cause Ca2+ desensitisations to promote relaxation of smooth muscle.
What is used to treat hypertension?
+why does this treatment work?
Vasodilators
Hypertension is high blood pressure, BP = TR x CO —> so if you decrease TPR by dilating the blood vessels, BP will decrease.
What is stable angina and how is it treated?
Pain in the chest during exercise/stress sue to insufficient coronary circulation.
Venodilation or arteriolar dilation. Surgery could also be used to open up arteries
What is vasospastic angina and how is it treated?
Coronary artery spasm which causes insufficient blood flow to heart.
Arterial/ arteriolar dilatation. Surgery could also be used to open up arteries
How does [Ca2+] for smooth muscle increase?
Noradrenaline/angiotensin II bind to external receptor.
This activates phospholipase C to catalyze PIP2 –> DAG + IP3.
IP3 causes sarcoplasmic reticulum to release Ca2+ (1) and DAG activates receptor gated channel to allow Na+ and Ca2+ (2) to enter the cell via electrochemical gradient.
The influx of Na+ cause depolarisation, which opens voltage gated channel to allow Ca2+ (3) to enter cell. The voltage gated channel is the main cause of [Ca2+] increase.
What releases NO?
Bradykinin ATP Histamine H+ CO2 ACh Also released by blood flow...
What does NO actually do to smooth muscle?
NO activates guanylate cyclase (GC). GC catalyses GTP–> cGMP
cGMP activates protein kinase G (PKG)
PKG causes K+ to be pumped out of the cell to cause membrane hyperpolarisation, which block voltage gated channels.
PKG causes Ca2+ to be pumped back into the sarcoplasmic reticulum and back out of the cellout of the cell.
PKG also causes Ca2+ desensitisation
How is cGMP regulated?
Phosphodiesterase (PDE) regulates cGMP
cGMP–> GMP
What activates the renin-angiotensin-aldosterone system?
A fall in blood volume, fall in blood Na+ or fall in blood pressure
What is the renin-angiotensin-aldosterone system?
Renin is released and bind to angiotensin molecule to form angiotensin I.
Angiotensin converting enzyme converts angiotensin I to Angiotensin II utilising bradykinin.
Angiotensin II is responsible for ADH increase, vasoconstriction, and aldosterone release.
What do ACE inhibitors do?
Block production of angiotensin II and inhibit bradykinin breakdown.
Reduced blood pressure, via vasodilation.
What are ARBs?
Angiotensin receptor blockers.
ARBs don’t affect bradykinin metabolism, and reduce blood pressure via vasodilation
What are CCBs and what are some examples?
Calcium channel blockers
Treats hypertension and angina.
Amlodipine (acts only on blood vessels) inhibits constriction of arterioles by blocking voltage gated Ca2+ channels, causing vasodilation.
Verapamil (acts on heart) reduces heart rate and contractile force by blocking voltage gated Ca2+ channels.
What is minoxidil?
K+ channel opener, which causes vadodilation
What is nicorandil?
K+ channel opener and a cGMP stimulator, which both cause vasodilation.
What do organic nitrates do to blood vessels?
‘a pharmacological endothelium’
An NO group is removed to cause the same effects on the blood vessels as NO –> vasodilation
What is the corpus cavernosum?
Network of blood vessels within the penis. When filled, erection occurs.
What does sildenafil do?
Blocks PDE5, which means theres more cGMP.
Erection of the penis is stronger/ lasts longer.
Can also treat pulmonary hypertnsion.
What does the pelvic nerve of the urinary tract do?
Releases ACh to contract detrusor and releases NO to relax the urethra.
Switches on to cause urination.
What does the hypogastric nerve of the urinary tract do?
Releases NA to relax the detrusor via B3 receptor and constricts urethra via a1 receptors.
Keeps bladder relaxed to allow it to fill up when switched on.
What does the pudendal nerve of the urinary tract do?
Releases ACh to constrict the external urethral sphincter via nicotinic receptors.
This is a somatic input and switches off to allow urination
What is myocardial infarction?
Heart attack due to coronary thrombosis
What are arrhythmias?
Lack of normal heart rhythm, leading to a fall in cardiac output
What is heart failure?
Insufficient cardiac output to meet body’s needs.
What effect does anticholinesterases have on the heart and why?
Slows the heart rate because cholinesterases are inhibited, increasing [ACh]. ACh slows the heart rate down (via the parasympathetic NS).