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4BBY1040 > Drug List > Flashcards

Drug List Flashcards

1
Q

What does Hemicholinium do?

A

Binds to cholinergic synapse membrane
Inhibits precursor uptake for ACh
This causes less synthesis of ACh

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2
Q

What does AMPT do?

A

Binds to Noradenergic synapses

Inhibits synthesis enzyme cascade for NA

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3
Q

What does Conotoxin do?

A

Inhibits calcium release from V gated channel

This prevents release of vesicles by exocytosis

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4
Q

What does Mg2+ do?

A

Blocks Ca2+ entry at neuromuscular junction

This causes less ACh release

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5
Q

What does Botox do (apart from cosmetic)?

A

Interferes with SNARE proteins inhibiting ACh vesicle fusion

This causes less ACh release

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6
Q

What does Clondine do?

A

Inhibits presynaptic receptor binding of NA at noradrenergic synapses
This prevents reuptake of NA by presynapse so enhances stimulation

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7
Q

What do MOAIs do?

A

Inhibits peripheral catecholamine breakdown

This increases NA and A avail to treat anxiety and depression

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8
Q

What does Fluoxetine do?

A

Used therapeutically to inhibit 5-HT reuptake at serotonergic synapses
This enhances 5-HT effect

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9
Q

What does Edrophonium do?

A

It is an anticholinesterase

it reverses muscle relaxation and is used in surgery.

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10
Q

What does Neostigmine do?

A

It is an anticholinesterase

Prolong deposition/ enhances transmission

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11
Q

What does Dyflos do?

A

It is an irriversible anticholinesterase

Prolong deposition/ enhances transmission

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12
Q

What does Ecothiopate do?

A

It is an irriversible anticholinesterase

Prolong deposition/ enhances transmission

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13
Q

What does Benzodiazepine tranquilisers do?

A

Bind to GABA receptor/Cl- ion channel complex to enhance channel opening
This increases effects of GABA.

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14
Q

What does Viagra do?

A

Inhibits breakdown of second messenger, cGMP produced by nitric oxide in erectile tissue; PDE5 inhibitor
Increased blood flow to genitals

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15
Q

What are some examples of nondepolarizing muscle relaxers, and what do they do?

A

Atracurium, vecuronium, tubocurarine

Reversibly bind to NAChR at NMJ
This relaxes muscles

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16
Q

What does Suxamethonium do?

A

Continuously stimulates receptor causing desensitization
Agonist on NAChR – NMJ
This relaxes muscles

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17
Q

What does Salbutamol do?

A

It is a Bronchodilator

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18
Q

What does Dobutamine do?

A

Agonist on b1 and b2 sympathetic adrenoreceptors

Increase CO; used to increase cardiac force of contraction in patients with acute heart failure (end stage)

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19
Q

What does Reserpine do?

A

Causes leakage of NT, inhibiting storage of Noradrenergic vesicles and dopaminergic vesicles
Less NA/NT release into synaptic cleft

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20
Q

What does L-DOPA do?

A

Its the precursor to dopamine

Excess L-DOPA increases production of dopamine

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21
Q

What does Guanethidine do?

A

Inhibits terminal depolarisation at Noradrenergic synapses and displaces NA

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22
Q

What do Amphetamines do?

A

Displaces NA and A to enhance sympathetic effect

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23
Q

What does Tyramine do?

A

Displaces NA or A and inhibits NA uptake.

This decreases gut motility, increases HR, force and BP

24
Q

What does Cocaine do?

A

Inhibits NA reuptake; interferes with action of NA transporter
Enhances sympathetic effect

25
Q

What do Tricyclic antidepressants do?

A

Inhibits NA reuptake to increase sympathetic effects

26
Q

What does Prazozsin do?

A

Antagonist on a1 adrenreceptors to reduce BP

27
Q

What does Propranolol do?

A

Antagonist on b1 and b2 adrenoreceptors.

Treats myocardial infarctions and angina

28
Q

What does Metoprolol do?

A

Antagonist on b1 adrenoreceptors

Reduces arrythimias due to sympathetic overactivity

29
Q

What does Phenylephrine do?

A

Agonist on a1 adrenoreceptors

Treats acute hypotension and nasal congestion

30
Q

What does Tizanidine do?

A

Aagonist on a2 adrenoreceptors

Is a muscles relaxant

31
Q

What does Amitriptyline do?

A

Inhibits NA uptake

Enhances sympathetic transmission

32
Q

What does Imipramine do?

A

Inhibits NA uptake to enhance sympathetic transmission

Also inhibits seratonin uptake and is an antidepressant

33
Q

What does a-methyl-p-tyrosine do?

A

Inhibits tyrosine hydroxylase

Prevents catecholamine synthesis

34
Q

What does Isoprenaline do?

A

Agonist on B2 adrenoreceptors and causes a fall in BP

Agonist on postsynaptic B1 adrenoreceptors in heart to increase rate and force

35
Q

What does Hexamethonium do?

A

Antagonist on ganglionic NAChR

Antihypertensive

36
Q

What does Phenoxybenzamine do?

A

Antagonist on a1 and a2 adrenoreceptors

Treats adrenal gland tissue tumor

37
Q

What does Trimetaphan do?

A

Antagonist on ganglionic NAChR. Sometimes used to control hypotension in surgery

38
Q

What does Atropine do?

A

Antagonist on muscarinic receptors

In surgery; blocks secretions; dilates pupils; reduces GI motility; treats LUTS

39
Q

What does Hyoscine do?

A

Antagonist on muscarinic receptors

Antimotion sickness; reduces GI motility; treats LUTS

40
Q

What does Ipratropium do?

A

Antagonist on muscarinic receptors

Bronchodilator

41
Q

What does Policarpine do?

A

Antagonist on muscarinic receptors

Ciliary contraction to treat glaucoma

42
Q

What does Bethanechol do?

A

Antagonist on muscarinic receptors

Stimulates gut motility; assists in bladder emptying

43
Q

What do ACE inhibitors do?

A

Reduces levels of angiotensin causing a vasodilating effect; inhibits in the renin-angiotensin-aldosterone system

44
Q

What does ARB inhibitors do?

A

Treat hypertension along with calcium channel blockers

45
Q

What does Amlodipine do?

A

Selective calcium channel blocker Treats angina and hypertension due to vasodilator effects

46
Q

What does Verapamil do?

A 
Nonselective calcium channel blocker
Treats angina and hypertension; class 4 antiarrhythmic drug (reduces excitability at SA and AV nodes)
47
Q

What does Amiodarone do?

A

Blocks repolarizing K+ channel; prolongs action potential and therefore refractory period of heart

48
Q

What does Lidocaine do?

A

Blocks fast sodium channel reducing excitability in cardiac muscle outside of SA and AV node in the heart

49
Q

What do organic nitrates do?

A

Acts on blood vessels to decrease preload decreasing cardiac workload and O2 demand; Treats angina

50
Q

What does Ivabradine do?

A

Inhibits pacemaker ‘funny’ current

Treats angina and heart failure by decreases cardiac O2 demand bc it slows diastole so more blood can reach the heart

51
Q

What does Digoxin do?

A

It is a positive inotrope

52
Q

What does Ranolazine do?

A

Decreases diastolic stiffness so is a positive inotrope

53
Q

What does Nicorandil do?

A

Ca2+ channel blocker

Decreases TPR decreases heart workload and O2 demand

54
Q

What does Oxybutynin do?

A

Treats overactive bladder

55
Q

What does Mirabegron do?

A

Treats overactive bladder

56
Q

What does Ambrisentan do?

A

Treats pulmonary hypertension

57
Q

What does Ileprost do?

A

Treats pulmonary hypertension

4BBY1040 (6 decks)

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