muscles Flashcards
what are the four general muscle functions?
- movement of bones or fluids
- maintaining posture and body positions
- stabilizing joints
- heat generation
what are the special characteristics of muscle tissue?
excitability, contractility, extensibility, elasticity
what is excitability?
ability to receive and respond to stimuli
what is contractility?
ability to shorten when stimulated
what is extensibility?
ability to be stretched
what is elasticity?
ability to recoil to resting length
muscle fiber=
muscle cell
my/o, mys/o, sarc/o
used to reference muscles
sarcolemma
plasma membrane of muscle fiber
sarcoplasm
cytoplasm of muscle fibers
what are the 2 myofilaments?
actin and myosin
fascicles
a muscle made up of densely packed groups of elongated cells
muscle fibers
smaller units in a fascicle
myofibrils
a muscle fiber made into even smaller units
sacromeres
myofibril made fo repeating units which are made up of two types of filaments
what are the structures of a skeletal muscle big to small?
muscle, fascicles, muscle fiber, myofibrils, sarcomere
epimysium
dense regular connective tissue surrounding entire muscle
perimysium
fibrous connective tissue surrounding groups of muscle fibers
endomysium
fine loose connective tissue surrounding fascicles
sarcoplasmic reticulum
surrounds myofibrils and stimulates muscle contractions
each myofibril is made up of repeating units called _____________
sarcomeres
a sarcomere is a functional unit of a ____________
muscle fiber
the sarcomere is composed of which two types of myofilaments?
thick and thin
_______ is a thick filament
myosin
__________ is a thin filament
actin
what does. myosin look like?
it has globular heads coming off of it, each head is attached to ATP
what does actin look like?
a twisted molecule with binding sites for myosin heads
A band:
contains only actin filaments giving them a lighter appearance
Z-line:
anchors the actin filaments and connects myofibrils to one another, represents edges of sarcomeres
H zone:
region where you find only myosin
M line:
line of protein that anchors myosin filaments together during a muscle contraction
how does skeletal muscle contract?
the movement of actin and myosin bands over eachother
which theory explains how a muscle contracts?
sliding filament theory
what does the sliding filament theory state?
that thin filaments slide across thick filaments, thereby shortening the sarcomere
what are the two requirements for skeletal muscle contractions?
activation and excitation-contracting coupling
what is activation?
neural stimulation at a neuromuscular junction
what is excitation-contraction coupling?
generation and propagation of an action potential along the sarcolemma
what is the final trigger in excitation-contraction coupling?
a brief rise in intracellular calcium levels
in order for muscles to contract they have to receive a ________ from the nervous system
stimulus
the place a muscle receives a stimulus from is the ______________
neuromuscular junction
skeletal muscles are stimulated by?
motor neurons
where do axons of motor neurons travel?
from the central nervous system to skeletal muscles
the place where an axon enters a muscle is called?
a motor end plate
4 steps to activation of skeletal muscle contraction:
- nerve impulse is sent to the neuromuscular junction
- calcium channels open and calcium enters the axon terminal, stimulating synaptic vesicles to release the neurotransmitter acetylcholine into the synaptic cleft
- acetylcholine binds to receptors on the motor end plate
- this causes the action potential to be sent through the muscle tissue
7 steps of excitation contraction coupling of skeletal muscle contraction:
- as the action potential is sent through the muscle tissue it passes through the T-tubules and into the sarcoplasmic reticulum
- calcium ions are released from the sarcoplasmic reticulum and invade the sarcolemma
- calcium ions bind to the troponin on actin and cause it to change shape
- tropomyosin now moves, which exposes the binding sites on the actin filaments
- the myosin kicks off the hydrolyzed ATP which allows the ADP to bond to actin
- the myosin heads pull the actin toward the m-line, shortening the sarcomere
- when calcium levels decrease the contraction stops and sarcomere lengthens
how long does acetylcholine continue to stimulate action potentials?
until it is destroyed
what destroys acetylcholine?
acetylcholinesterase