Muscle Relaxers Flashcards

1
Q

What is cyclobenzaprine for?

A

Muscle spasm generic oral drug, related to amitriptyline, ineffective for pain 2ndary to cerebral or spinal cord dz; also used off label in FM

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2
Q

Cyclobenzaprine MOA?

A

Central action, maybe at brainstem?

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3
Q

Cyclobenzaprine met/elim?

A

Enterohepatic recirculation and CYP3A4, 1A2, and 2D6; caution in liver failure

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4
Q

Cyclobenzaprine ADE’s?

A

Anticholinergic = opposite of SLUDGEBBB that are additive with other anti-cholindergics (GI=paralytic ileum). CNS depression/drowsiness. QT prolongation

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5
Q

Tizanidine use?

A

Oral for MS, Spasticity, and spinal cord trauma

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6
Q

Tizanidine MOA?

A

Agonist of presynaptic a2 receptors = decrease activation of polysynaptic motor neurons and reduction in motor tone (not strength!); similar to clonidine but clonidine is mostly relaxation of vasc smooth muscle and Tizanidine only had 10% vascular potency compared to clonidine

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7
Q

Tizanidine met/elim?

A

Extensive FP; short half life; renal elim of long lasting metabolites; titrate to effect with renal deficiency

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8
Q

Tizanidine ADEs?

A

Hepatits, rebound hypertonicity in muscle or rebound tachycardia/HTN, additive CNS depression, additive hypotension, asthenia, and xerostomia

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9
Q

Tizanidine monitoring?

A

LFTs

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