Muscle Flashcards
Outer most layer; skin and neuronal tissues
Ectoderm
Middle germ layer; muscle, fat, bone tissues
Mesoderm
Inner layer; respiratory and digestive tracts
Endoderm
What does myo- mean?
Muscle
Increase in number
Proliferation
Fuse and express muscle-specific gene
Differentiation
Myotube or myofiber
Maturation
MRF’s
Proliferation, Differentiation, Maturation
What does MRF stand for?
Myogenic Regulatory Factors
What do MRF’s help do?
Commit cells to myoblasts; family of transcription factors that ‘turn on’ transcription of other genes in the nucleus
Whats more preferred?
Proliferation
The cell cycle phases:
G1, S, G2, M
G1 Phase
3-12 hours; Environmental cues signal continuance
S Phase
DNA Synthesis
G2 Phase
Remodeling to accommodate mitosis
M Phase
Mitosis; Cell division
G0 Phase
Alternative G1 phase; Cells remain capable of proliferation without dividing; dormant; satellite cells
Satellite cells proliferate to repair muscle if damaged
G0 Phase
Myotube
Multi-nucleated; Nuclei are centrally located; Cannot contract; Mature into muscle fiber; Synthesize myofibrillar proteins and assembles them into myofibrils; Nuclei are unable to divide; Cannot create new myoblast
Go from mono-nucleated to multi-nucleated
Muscular precursor; muscle cell