Muscarinic Antagonists (Parasympatholytic Agents)

Question 1

**What are musky ANTagonists?

Answer 1

compounds that competitively block musky receptors…(inhibit all PS fxns and S Ch activity)

Question 2

Who do they compete with, reversible or naw?

Answer 2

compete with ACh for musky R, effect reversible, but may persist for hours or days

Question 3

**What happens at doses in excess of those employed clinically?

Answer 3

they can also block nicky Ch R at autonomic ganglia if given at HIGH enough doses

Question 4

What are three musky ANTagonists

Answer 4

1. ATROPINE
2. SCOPOLAMINE
3. GLYCOPYRROLATE

Question 5

**ATROPINE

Answer 5

a. allay the urgency and frequency of micturition
b. to relieve HYPERmotility of colon
c. relieve HYPERtonicity of the small intestine
d. tx of ChE inhibitor induced poisoning
e. ophtho: induce mydriasis and cycloplegia (aka paralysis of the ciliary mu)
f. reverse (vagal) bradycardia

Question 6

**SCOPOLAMINE

Answer 6

(-more of a sedative effect than atropine)

• used in preparation for surgical anesthesia to minimize secretions
• tx of nausea and vomiting associated with motion sickness + chemo-induced nausea

Question 7

**GLYCOPYRROLATE

Answer 7

-prevent OVERstimulation of the gut during reversal of neuro.mu blockade

Question 8

Atropine poisoning

Answer 8

“Blind as a bat, mad as a hatter, red as a beet, hot as a hare, dry as a bone, the bowel and bladder lose their tone, and the heart runs alone”