Muscarinic Antagonists

Question 0

Atropine toxicity

Answer 0

Increases body temperature (decreases sweating). Rapid pulse. Dry mouth. Flushed skin. Cycloplegia. Constipation. Disorientation. Can cause acute angle-closure glaucoma in the elderly. Urinary retention in men with prostatic hyperplasia. Hyperthermia in infants.
“ hot as hare, dry as a bone, red as a beet, blind as a bat, mad as a hare.”

Question 1

Atropine site of action and clinical application.

Answer 1

Muscarinic Antagonist. Treats Bradycardia & ophthalmic application.
Eye: Produces mydriasis (dilates pupils) and cycloplegia ( paralyze the ciliary muscle so no accommodation).
Airway: decreases secretions.
Stomach: decreases acid secretions
Gut: decreases motility
Bladder: decreases urgency in cystitis
Blocks DUMBBELSS: anticholinergic poisoning

Question 2

Homatropine site of action and application

Answer 2

Muscarinic antagonist.

Eye: Produces mydriasis (dilates pupils) and cycloplegia ( paralyze the ciliary muscle so no accommodation).

Question 3

Tropicamide site of action and application

Answer 3

Muscarinic antagonist.

Eye: Produces mydriasis (dilates pupils) and cycloplegia ( paralyze the ciliary muscle so no accommodation).

Question 4

Benztropine site of action and application

Answer 4

Muscarinic antagonist. CNS. PARKinsons disease. “park my Benz “

Question 5

Scopolamine site of action and application.

Answer 5

Muscarinic antagonist. CNS. Motion sickness.

Question 6

Ipratropium site of action and application

Answer 6

Muscarinic antagonist. Respiratory. Asthma, COPD. “I pray I can breath.”