Muscarinic Antagonists

Question 1

Atropine’s natural source

Answer 1

Belladonna flower (means beautiful lady), Jimson weed
Alice at table holding flower

Question 2

Scopolamine

Answer 2

motions sickness
walrus with scope - has large eye at end = mydriasis
CNS - wearing hat
eye patch because it’s transdermal patch

Question 3

antimuscarinic effects on heart

Answer 3

block m2 activation of SA and AV nodes –> increase rate.
queen of hearts has jewels by nodes
rabbit with heart watch = tachycardia

Question 4

antimuscarinic effects on airway and drugs that work there

Answer 4

dilate airways
ipratropium, tiotropium are inhaled bronchodilators
catapillar is smoking (maybe opium), blue (like blue bloater)
TIOoo smoke rings last longer

Question 5

Bladder effects and drugs that work there:

Answer 5

reduce bladder spasms
oxybutynin = ox butler turning off water
tolterodine = turtle

Question 6

2 drugs for parkinson’s

what receptor do they block

Answer 6

benztropine = benz car
trihexyphenidyl = 3 hex car
M1 receptor 
car is vibrating becuase they block the tremor 
extrapyramidal sx = "extra parking" cone

Question 7

Side effects of antimuscarinics

Answer 7

hot as a hare = inhibit M3 on sweat glands
Dry as a cracker = decreased salivation and lacrimation
Blind as a bat = bat by the walrus
high pressure as a kettle = can cause glaucoma
mad as a hatter = hallucinations, sedation, agitation

Question 8

drugs that weren’t included that are on the first aid page

Answer 8

HOMatropine
Tropicamide (think of Alice drinking something tropical)

Glycopyrrolate - reduces airways secretions pre-operatively

hyoscyamine
dicyclomine - both for IBS

solifenacin - same as oxybutunin and tolterodine = the turtle and ox butler are fenced in