Muscarinic Agonists Flashcards
Major clinical manifestations of neuropathy?
Other stuff – but they mention autonomic dysfunction.
Ok fine – this is a shitty flashcard.
Most important clinical form of autonomic neuropathy?
Cardiovascular autonomic neuropathy
Effects of alcoholism/chronic liver disease on ANS?
Autonomic, mainly vagal dysfunction
Peripheral arterial vasodilation and increased plasma catecholamine concentrations.
How do people get botulism toxin poisoning?
Food contaminated with toxin, open wound (IV injection site), botox injection
Botulinum toxin interacts with _________ proteins.
This causes what effects?
SNARE proteins.
No vesicle Ach release
T or F. Hyperthyroidism is a contraindication for the use of murcarinic agonists.
T
Most common cause of hyperthyroidism?
Grave’s Disease
Common symptoms of Grave’s Disease
Looks like hyperadrenergic state Hot/Sweating Irregular heartbeat Diarrhea Weightloss HTN
Treatment for Grave’s Disease?
beta blockers
Relationship between the thyroid and ANS?
- Adrenal glucocorticoids inhibit T3 formation
- Common unction to maintain energy expenditure homeo.
- Adrenergic desensitization can cause hypothyroidism (also, the opposite with sensitization)
Main causes of hypothyroidism?
Iodine deficiency (in foreign countries) or Hashimoto’s
Muscarinic receptors are named after…
Muscarine, the first parasympathomimetic
When would you clinically use muscarine?
Don’t.
It’ll cross yo blood brain barrier and give you the shakes.
(in medical world…convulsions)
Wait…if muscarine gets all up in your brain, why can we take other muscarinic drugs?
Add in a quartanary ammonum to limit the distribution in the CNS
What’s the downside to the ammonium present on muscarinic meds?
Low GI absorption means it usually have to be injected or in a topical cream
