Adrenergic agonists II

Question 1

beta 1 receptors are most importantly located at….

beta2?

Answer 1

cardiac muscle

smooth muscle of bronchioles

Question 2

first in class beta agonist?

Answer 2

isoproterenol

Question 3

Effects of isoproterenol

Answer 3

Bronchodilation

Increased CO

Question 4

Uses of isoproterenol

Answer 4

Asthma
COPD
Cardiostimulant

Question 5

Who are the second generation beta agonists?

Answer 5

Metaproterenol
Terbutaline
Albuterol
Salmeterol

Question 6

What do metaproterenol and terbutaline do?

Answer 6

Selective beta2 agonists
Bronchodilation
Longer Duration than isoprotenenol

Question 7

Uses of metaproterenol and terbutaline?

Answer 7

Asthma
COPD
Terbutaline used a tocolytic (stops contractions)

Question 8

Whats the chemistry word for the type of drugs that includes metaproterenol and terbutaline?

Answer 8

Resorcinol derivatives

Question 9

What are Albuterol and Salmeterol?

Answer 9

Selective beta2 receptor agonists
Bronchodilation
Longer duration than isoproterenol

Question 10

Uses for Albuterol and Salmeterol?

Answer 10

Asthma and COPD

Question 11

Unique traits of Salmeterol and Formoterol?

Answer 11

Onset is much later (S-10min, F-Under 5) - NOT FOR ACUTE

Question 12

Molecular activity of Dobutamine?

Answer 12

+enantiomer – potent beta1 agonist, alpha1 receptor anta.

-enantio. – potent alpha1 agonist, low beta potency

Question 13

Dobutamine effect?

Answer 13

positive ionotropic, little chronotropic effect

Question 14

Use for Dobutamine?

Answer 14

acute heart failure

shock

Question 15

How does the indirect-acting sympathomimetic COCAINE work?

Answer 15

Blocks the NE Reuptake Transporter

Question 16

How does the indirect-acting sympathomimetic AMPHETAMINE work?

Answer 16

Makes the NE transporter work in reverse

Also seems to hit VMAT and MAI to inc. NE

Question 17

Five examples of indirect-acting sympathomimetics?

Answer 17

Amphetamine, Pseudoephedrine, Ephedrine, Phenylpropanolamine, Tyramine

Question 18

Clinical uses of Amphetamines?

Answer 18

ADHD, Narcolepsy, Anorexiant

Question 19

Clinical uses of non-amphetamine indirect-acting sympathomimetics?

Answer 19

Nasal decongestants
(ex. pseudoephedrine)

Question 20

Effect of Ephedrine

Answer 20

Direct agonist activity at adrenergic receptors

Question 21

Effect of pseudoephedrine

Answer 21

Reduced agonist activity

Major mechanism is via transport reversal

Question 22

How do you make meth?

Answer 22

Pseudoephedrine + Lithium + NH4