Adrenergic agonists II Flashcards
beta 1 receptors are most importantly located at….
beta2?
cardiac muscle
smooth muscle of bronchioles
first in class beta agonist?
isoproterenol
Effects of isoproterenol
Bronchodilation
Increased CO
Uses of isoproterenol
Asthma
COPD
Cardiostimulant
Who are the second generation beta agonists?
Metaproterenol
Terbutaline
Albuterol
Salmeterol
What do metaproterenol and terbutaline do?
Selective beta2 agonists
Bronchodilation
Longer Duration than isoprotenenol
Uses of metaproterenol and terbutaline?
Asthma
COPD
Terbutaline used a tocolytic (stops contractions)
Whats the chemistry word for the type of drugs that includes metaproterenol and terbutaline?
Resorcinol derivatives
What are Albuterol and Salmeterol?
Selective beta2 receptor agonists
Bronchodilation
Longer duration than isoproterenol
Uses for Albuterol and Salmeterol?
Asthma and COPD
Unique traits of Salmeterol and Formoterol?
Onset is much later (S-10min, F-Under 5) - NOT FOR ACUTE
Molecular activity of Dobutamine?
+enantiomer – potent beta1 agonist, alpha1 receptor anta.
-enantio. – potent alpha1 agonist, low beta potency
Dobutamine effect?
positive ionotropic, little chronotropic effect
Use for Dobutamine?
acute heart failure
shock
How does the indirect-acting sympathomimetic COCAINE work?
Blocks the NE Reuptake Transporter
How does the indirect-acting sympathomimetic AMPHETAMINE work?
Makes the NE transporter work in reverse
Also seems to hit VMAT and MAI to inc. NE
Five examples of indirect-acting sympathomimetics?
Amphetamine, Pseudoephedrine, Ephedrine, Phenylpropanolamine, Tyramine
Clinical uses of Amphetamines?
ADHD, Narcolepsy, Anorexiant
Clinical uses of non-amphetamine indirect-acting sympathomimetics?
Nasal decongestants (ex. pseudoephedrine)
Effect of Ephedrine
Direct agonist activity at adrenergic receptors
Effect of pseudoephedrine
Reduced agonist activity
Major mechanism is via transport reversal
How do you make meth?
Pseudoephedrine + Lithium + NH4
