Muscarinc Agonists Flashcards

Question 1

Q

Bethanechol

Answer

A

M3 
Bladder &amp; GI
Ester
Resistant to hydrolysis
Postop urinary retention (avoid catheter)

Question 2

Q

Methacholine

Answer

A

M
Ester
Inhalation
Dx bronchial airway hyperreactivity

Question 3

Q

Pilocarpine

Answer

A

All M, target M3
Ester
Partial agonist
Xerostomia (Sjogren’s)
2nd line wide angle glaucoma
Target M3 ciliary body —> increase aq humor —> decrease IOP

Question 4

Q

Cevimeline

Answer

A

M1/M3
Lacrimal &amp; salivary glands
Longer DOA than pilocarpine
Sjogrens
Radiation not approved
Fewer side effects than pilocarpine

Question 5

Q

General properties of muscarinic agonists

Answer

A

more selective
longer DOA
ester DO NOT penetrate BBB
alkaloids DO penetrate BBB

Question 6

Q

What are muscarinic agonists used for?

Answer

A

Urinary retention
Xerostomia
Dx bronchial hyperreactivity
Ophthalmic indications

Question 7

Q

Most common side effects of muscarinic agonists

Answer

A

sweating
hypotension
GI effects (cramping, diarrhea)

Question 8

Q

Contraindications of muscarinic agonists

Answer

A

Hyperthyroidism
Asthma/COPD
Peptic ulcer

Question 9

Q

Receptor antagonist of muscarinic agonists

Question 10

Q

Physiological antagonist of muscarinic agonists

Answer

A

Epinephrine

Question 11

Q

Toxic doses of muscarinic agonists

Answer

A

Full range of M effects possible

Muscarinc Agonists Flashcards

(11 cards)