Muscarinc Agonists Flashcards
1
Q
Bethanechol
A
M3 Bladder & GI Ester Resistant to hydrolysis Postop urinary retention (avoid catheter)
2
Q
Methacholine
A
M
Ester
Inhalation
Dx bronchial airway hyperreactivity
3
Q
Pilocarpine
A
All M, target M3 Ester Partial agonist Xerostomia (Sjogren’s) 2nd line wide angle glaucoma Target M3 ciliary body —> increase aq humor —> decrease IOP
4
Q
Cevimeline
A
M1/M3 Lacrimal & salivary glands Longer DOA than pilocarpine Sjogrens Radiation not approved Fewer side effects than pilocarpine
5
Q
General properties of muscarinic agonists
A
- more selective
- longer DOA
- ester DO NOT penetrate BBB
- alkaloids DO penetrate BBB
6
Q
What are muscarinic agonists used for?
A
Urinary retention
Xerostomia
Dx bronchial hyperreactivity
Ophthalmic indications
7
Q
Most common side effects of muscarinic agonists
A
- sweating
- hypotension
- GI effects (cramping, diarrhea)
8
Q
Contraindications of muscarinic agonists
A
Hyperthyroidism
Asthma/COPD
Peptic ulcer
9
Q
Receptor antagonist of muscarinic agonists
A
Atropine
10
Q
Physiological antagonist of muscarinic agonists
A
Epinephrine
11
Q
Toxic doses of muscarinic agonists
A
Full range of M effects possible
