Adrenergic Agonists

Question 1

Epinephrine receptors

Answer 1

A1, a2, b1, b2

Question 2

Norepinephrine receptors

Answer 2

A1, a2, b1

Question 3

Isoproterenol receptors

Answer 3

B1, b2

Question 4

Dopamine receptors

Answer 4

D1 > B2 > a1

Question 5

Dobutamine receptors

Answer 5

B1

Question 6

Phenylephrine receptors

Answer 6

A1

Question 7

Clonidine recpetors

Answer 7

A2

Question 8

Terbutaline receptors

Answer 8

B2

Question 9

Mirabegron receptors

Answer 9

B3

Question 10

Ephedrine recpeotrs

Answer 10

Non selective a/b; mixed acting

Question 11

Norepinephrine use

Answer 11

Severe hypotensive states

Preferred vasopressor for septic shock

Question 12

Epinephrine use

Answer 12

Prolong local anesthetics (a1)
Anaphylactic shock (a1, B1, B2)
Ashtma (B2)
Topical hemostasis (a1)
Cardiac arrest (B1)

Question 13

Isoproterenol use

Answer 13

AV block
Cardiac arrest
Bronchospasm during anesthesia

Question 14

Dopamine use

Answer 14

Shock (esp accompanied by low CO & compromised renal fcn)

Maintain systemic BP in hypotensive patients w/ sepsis

Question 15

Dobutamine use

Answer 15

Cardiac stimulant for short term treatment of severe refractory CHF

Question 16

Phenylephrine use

Answer 16

Nasal decongestant
Vasopressor
Mydriatic
Detumescent

Question 17

Clonidine use

Answer 17

HTN
ADHD
Severe pain (epidural)
Many off label uses

Question 18

Terbutaline use

Answer 18

Decrease airway resistance in asthmatics & COPD

Off label: tocolytic: suppress premature labor

Question 19

Mirabegron use

Answer 19

Overactive bladder

Question 20

Ephedrine use

Answer 20

Anesthesia induced hypotension

Question 21

Methylphenidate use

Answer 21

ADHD: immediate onset

Narcolepsy

Question 22

Atomeoxetine use

Answer 22

ADHD: re-uptake inhibition immediate, efficacy delayed (1-3 weeks)

Less abuse potential, not controlled

Question 23

SE epinephrine

Answer 23

Hypertensive crisis (a1)
Dysrhythmias (B1)
Angina (a1, B1)
Extravasation induced necrosis (a1)
Hyperglycemia (B2)

Question 24

DI of epinephrine

Answer 24

MAOI (pheneizine)
TCA (imipramine)
General anesthetics (halothane)
A & B blockers (prazosin, propranolol)

Question 25

SE of dobutamine

Answer 25

Tachycardia/arrhythmias
THN

Intensified by MAOIs (90% dose decrease in these patients)

Question 26

CI in dobutamine

Answer 26

Ischemic heart disease

Question 27

Phenylephrine toxicity

Answer 27

Reflex bradycardia (decrease CO), excitability, restlessness, HTN

Overdose: vomiting, HTN, palpitations, arrhythmias

Question 28

SE clonidine

Answer 28

Bradycardia
Dry mouth
Sedation

Rebound HTN upon abrupt withdrawal

Question 29

Terbutaline SI

Answer 29

Tremor, hyperglycemia

Tachycardia at increased dose

Question 30

BBW for terbutaline

Answer 30

Adverse CV events & death in pregnant women

Question 31

CI mirabegron

Answer 31

GI (Nausea, diarrhea, const)
Tachycardia
Urinary retention
Increase BP

Question 32

CI of mirabegron

Answer 32

Inhibits CYP2D6

M antagonists

Question 33

Ephedrine SE

Answer 33

HTN

Insomnia

Question 34

Methylphenidate SE

Answer 34

CV events, peripehral vasculopathy & priapism (rare)
Insomnia
Appetite decrease
Tics

Tolerance, physical dependence & withdrawal

Question 35

BBW methylphenidate

Answer 35

Abuse potential

Question 36

SE atomeoxetine

Answer 36

Dizziness
Insomnia
Decrease dappetite
Priapism

Orthostatic tachycardia
Increase BP

Suicidal thoughts children/adolescents

Question 37

Catecholamines

Answer 37

Not orally effective
Short DOA
Do not cross BBB

Question 38

Non-catecholamines

Answer 38

No catechol group
Orally effective
Long DOA CNS effects