Murman et al article

Question 1

What percentage of people have normal
biomarkers at age 50?

Answer 1

100%

Question 2

What percentage of people have normal
biomarkers at age 89?

Answer 2

17%

Question 3

What are the new diagnostic categories for AD incorporating biomarkers x4?

Answer 3

Stage 1 = have cerebral amyloidosis only
Stage 2 = have amyloidosis plus neurodegeneration but no cognitive decline
Stage 3 = have amyloidosis, neurodegeneration, subtle cognitive decline, but no functional decline
Stage 4 = have amyloidosis and neurodegeneration, with measurable cognitive and functional decline.

Question 4

importance of the hippocampus: size, plasticity, factors associated with decreased hippocampal size increasing the risk for AD. true or false

Answer 4

true

Question 5

What factors are associated with decreased hippocampal size?

Answer 5

diabetes mellitus
hypertension
obesity
hypoxic brain injury
obstructive sleep apnea
clinical depression
bipolar disorder
alcoholism
head trauma