Multisystem Conditions Flashcards
__ in 5 Canadians will get cancer, __ in 4 will die from cancer
2;1
Top 3 cancers in males?
- prostate
- lung
- colon
Top 3 cancers in females?
- breast
- lung
- colon
Top 3 cancer mortality male?
- lung
- colorectal
- prostrate
Top 3 cancer mortality female?
- lung
- breast
- colon
TMN cancer staging system?
T = tumour (Tx, T0, T1-4) N = nodes (lymph) - Nx, N0, N1-3 M = mets (distant ones) - Mx,M0, M1
Cancer stages?
0 - 4
Stage __ cancer = in situ
0
Stage __ - __ cancer = cancer has extended beyond organs in which it first developed
1-3
Stage __ cancer = cancer has spread to different organs
4
5 possible Rx for cancer ?
- Sx
- chemo
- radiation
- hormone replacement therapy
- biological or genetic Rx to destroy ca cells
Name 5 side effects of chemo
any of…
1) alopecia
2) mucositis
3) pulmonary fibrosis
4) cardiotoxicity
5) renal failure
6) sterility
7) myalgia
8) neuropathy
Name 5 side effects of radiation
any of…
1) FATIGUE
2) skin irritation
3) scar tissue
4) hair loss
5) temporary change in skin colour
6) swallowing discomfort
4 PT Rx for cancer
- fatigue management
- function and mobility management
- physical symptom management
- psychological symptom management
Exercise precautions for ca pts? (5)
- swollen ankle
- fatigue
- vomiting / diarrhea
- unexplained weight loss or gain
- SOB w/ low level of exertion
Exercise CI’s for ca pts? (9)
- racing pulse
- fever
- pain in back or neck, or bone, calf pain and chest pain
- nauseated while exercising
- confused or disoriented
- dizzy or faint
- blurred vision
- sudden SOB
- very weak or tired
For metastatic disease, you need ____ ______ orders from MD!
weight bearing (cannot just have AAT!)
Metastatic disease pts: ask about any new _______ symptoms
neurological (B/B, unrelenting pain)
Normal Hb levels males = __ - __ g/dl
14-18
Normal Hb levels females = __ - __ g/dl
12-16
Anemia: exercise will need to be scaled back if below __ g/Dl
8
_________ = decreased WBC
neutropenia
WBC count should be > ____ mcl
1000
Risk of infection if absolute neutrophils falls below ____ MCL
500
Neutropenia: avoid exercise if pt has fever > ___
37.5
_________ = low platelet count
thrombocytopenia
Normal platelet count = __ - ______ /mcl
150-400,000
Thrombocytopenia: if < _____ MCL = avoid any activities w/ contact or risk of falling
50,000
Thrombocytopenia: Rx b/w __ - ____ MCL = low weights, stationary bike LOW resistance, walking or ALDs
40-60000
Thrombocytopenia: Rx b/w __ - _____ mcl = low intensity exercise, low weights, stationary bike NO resistance or minimal, walking and ADLs
20-40000
Thrombocytopenia: if < _______ = risk of spontaneous bleed unrelated to trauma
20000
Thrombocytopenia: Rx b/w __ - ______ mcl = doctor approval, active ROM exercises, walking, ADLs
10-20000
Thrombocytopenia: if below ________ = spontaneous CNS, GI or resp bleed; no exercise, only essential ADLs, prevent falls and injury
10,000
_______ lymphedema = rare, inherited condition where developmental problems occur in lymph vessels
primary
______ lymphedema = D/T damage or obstruction to normally functional lymph vessels and nodes
secondary
6 risk factors for lymphedema ?
- radiation
- axillary node dissection
- arm infection / virus
- weight gain since operation
- obesity (BMI > 25)
- older age
4 things to do to prevent lymphedema?
- skin care
- activity / lifestyle
- avoid limb constriction
- avoid extreme temp
Measuring lymphedema: > __ cm difference between size indicates lymphedema
2
3 ways to measure lymphedema?
- circumferential
- water displacement
- perometer and bioelectrical impedance
HIV can be transmitted through urine, sweat and vomit (T/F)
FALSE
Result of AIDS = loss of immune system function, decrease in ____ helper T cells
CD4+
3 ways to Dx AIDS?
- clinical findings
- systemic evidence
- lab evidence
Lab evidence HIV: HIV-1 ______ test, CD4 cell count __ - ___ / ml
antibody; 200-500
Normal CD4 cell count?
b/w 800-1200
HIV: want to keep viral ____ as low as possible
load
Med Rx for HIV?
- multidrug antiviral therapy
2. symptomatic treatment
_______ = antibody mediated demyelination of schwann cells in PNS from spinal nerves –> terminating fibers
GBS
GBS: __/3 people had recent illness in last 30 days
2
4 S/S of GBS?
- onset to peak 4 weeks
- rapid ascending motor weakness and distal sensory loss
- stocking and glove pattern of loss
- absent DTR!
5 PT rx for GBS?
- positioning
- joint protection
- chest Rx, mobilization
- strength
- ROM
GBS trajectory is usually opposite to what other disorder?
ALS!
______ ______ = can involve skin and other multi system (organs, arthritis, etc)
lupus erythematous
8 S/S of lupus erythematous?
- skin (butterfly rash)
- localized erythema
- localized edema
- alopecia
- photosensitivity
- mucusal ulcers
- Raynauds
- joint effusion
Lupus erythematous = may see _____ (malar) rash
butterfly
Dx of lupus erythematous?
+ve serum antinuclear antibodies (ANA), symmetric arthritis
_______ = chronic disease primarily affecting skin, characterized by sclerosis
scleroderma
Scleroderma provokes massive ______ tissue response
fibrotic
Name 6 side multi system side effects caused by scleroderma
- joint contractures
- pulmonary fibrosis
- HTN
- renal side effects
- GI dysmotility
- Raynauds
Dermatomyositis / polymyositis = inflammatory CT disorder characterized by _______ limb girdle weakness
proximal
Dermatomyositis affects skin, and polymyositis affects muscles (T/F)
FALSE; dermatomyositis affects both skin and muscles!
_______ = hereditary bleeding disorder; body unable to control blood clotting / coagulation
haemophilia
Type __ haemophilia = most common of hereditary clotting factor deficiencies
A
Type A haemophilia = __ linked recessive ; males have condition, females carry gene
X
If father has haemophilia, mother doesn’t carry gene: male child (can/cannot) carry gene; female child = ______ carrier
CANNOT; obligate
Most common problem w/ haemophilia ?
bleeding into joints !
Haemophilia: joint bleeding symptoms ?
- joint tightness + no pain
- tightness + pain
- swollen, hot to touch, hard to move
- all ROM lost + severe pain
- bleeding slows in few days b/c joint is full of blood
If haemophilia / joint bleeds are not treated will cause disabling ______
arthritis
2 Rx for haemophilia ?
- recombinant factor VIII infusion
2. dismopressin (mild hemophila)
Red flags in rheumatic diseases? (6)
- #
- septic arthritis
- malignancy
- central cord S/S
- focal/diffuse muscle weakness
- burning / numbness paresthesia
4 questions to ask in rheumatic diseases?
- red flags
- inflammation in joint or around joint
- focal or widespread
- acute or chronic
If inflammation is (in/around) joint, it will effect multiple ROM, no focal TOP, swelling common
IN
Focal arthritis = < __ joints, widespread = > __ joints
3;3
Acute arthritis = < __ weeks, chronic = > ___ weeks
6
Inflammatory condition = when is pain worst? Non inflammatory ?
AM; after use
Swelling in inflammatory conditions ?
moderate to severe
Swelling in non-inflammatory conditions ?
mild
Is there warmth in inflammatory conditions? Non inflammatory ?
sometimes; no
Inflammatory conditions = morning stiffness > __ hour; non inflammatory conditions = morning stiffness < __ minutes
1; 30
Inflammatory conditions = often increased in _____
ESR
______ features are often present in inflammatory conditions, absent in non inflammatory conditions
SYSTEMIC
Example inflammatory condition? Non inflammatory condition ?
RA; OA
Main feature of RA = _______
synovitis
RA = ______ pattern
symmetrical
RA: dense cellular membrane (_______) spreads over articular cartilage
pannus
RA: _____ erodes underlying cartilage and bone
pannus
RA: w/ time, pannus may extend to the opposite articular surface creating what 3 things?
- fibrous scar tissue
- adhesions
- bony ankylosing
8 RA criteria?
- morning stiffness > 1 hour (6 weeks)
- arthritis of >/= 3 joints (6 weeks)
- arthritis of hands
- symmetric arthritis (6 weeks)
- rheumatoid nodules
- serum rheumatoid factor
- radiographic changes
- abnormal antibody (80% in those w/ RA)
What is the abnormal antibody found in pts with RA?
HLA-DR4
5 other conditions besides RA HLA - DR4 is found in ?
- ILD
- chronic hepatitis
- IPF
- normal aging adults
- SLE
3 things that increase risk of RA?
- giving birth
- cigarette smoke
- pollution
7 S/S of RA?
- pain
- fatigue
- stiffness
- swelling
- joint deformity
- mm atrophy
- extra-articular features
Meds for RA (3 groups)?
- DMARDS / biologics
- methotrexate
- NSAIDS, tylenol, cortisone
______/ _____ stope the RA disease process
DMARDs / biologics
________ prevents permanent joint damage / premature death from RA
methotrexate
RA: With ______ , it is important to educate your pt on effects on liver and reproductive organs
methotrexate
NSAIDS, tylenol and cortisone do not stop RA disease process but improve inflammation and pain, but not ROM (T/F)
FASLE - DO improve RIM
RA rehab in ______ phase = energy conservation, ice, splints, gentle ROM
acute
RA rehab acute phase: NO _______ !
stretching
Name 5 rehab goals for RA chronic phase.
Any of…
- relieve pain
- splints, exercise (gentle ROM)
- relaxation / rest
- dec stiffness (gentle ROM)
- aquatic exercise
- functional exercises
- prevent deformity
- fall prevention
- moderate intensity PA
4 R’s of surgical management of RA?
- remove (MTP resection
- re-align (tendon rupture)
- rest (arthrodesis)
- replace (arthroplasty)
Name the 3 steps in a joint count assessment.
STOP!
- joint effusion (2 or 4 finger technique)
- joint line tenderness
- stress pain
Name 7 commonly affected joints in RA
- AA joint
- TMJJ
- GHJ
- AC joint
- elbow
- hip
- knee
Elbow in RA: superior ______ joint commonly involved, leading to erosion of ______ head
radioulnar; radial
RA: ______ ligament may be affected at AA joint
transverse
RA: humeral head may move _______ at GHJ
superiorly
_____ _____ = 1st MTP synovitis, big toe is lateral, ligament laxity and erosion
hallux valgus
Hallux valgus: subluxation –> dislocation, proximal phalanx drifts _______, causing _______ of mid foot
laterally; pronation
______ ________ = synovitis, displacement of the flexors, unopposed extensors pull the proximal phalanx into hyperextension
MTP subluxation
MTP subluxation: MT heads prolapse and get dislocation and _______ drift of toes
lateral
Sign of MTP subluxation?
callouses
______ _____ = MTP synovitis. MTP ext, PIP + DIP flexion
claw toe
Claw toe: often in all toes except?
big toe
_____ ______ = MTP and PIP synovitis, usually involves __ toe, flex of PIP and hyperextension of DIP
hammer toe ; 2nd
Hammer toe is similar to what finger deformity ?
boutonniere
_____ _____ = flexion of DIP, affects longest toe
mallet toe
____ _____ = contracture of instrinic muscles w/ dorsal subluxation of lateral extensor tendons
swan neck
Swan neck = ____ of MCP, hyperextension of _____ and flexion of ____
flexion; PIP; DIP
Test for swan neck deformity ?
Bunnel Littlers
_________ = rupture of central tendinous slip of extensor hood
boutonniere
Boutonnières = zig - zag deformity; ______ of MCP, _____ of PIP and _______ of DIP
extension; flexion; hyperextension
Test for boutonnières?
central slip tendinitis
_______ ______ = most common hand deformity in RA;
ulnar drift
ulnar drift = involves synovitis of ____ + structural differences; causes _____ subluxation / laxity of MCP in radial collateral ligaments
MCP; volar
Tests for ulnar drift deformity ?
radial collateral ligament test; extensor tendon subluxation test
Rx for ulnar drift?
- lateral finger walking
2. joint protection
Test for thumb deformities?
grind and crank
2 Rx for thumb deformities?
- web space massage / stretch
2. opposition and abduction exercises
DRUJ instability: _______ at joint, stretches ulnar carpal ligaments, ulnar head will sublux ______
synovitis; dorsally
DRUJ instantly: _____ is displaced and becomes a FLEXOR tendon
ECU
Test for DRUJ instability ?
ballottement test
________ contracture = contract of the palmar fascia
Dupuytrens
Dupuytrens = affects MCP’s and PIPs of ___ and ___ digits
4th, 5th
____ _____ = thenar muscle wasting w/ first digit moving dorsally until in line w/ second
ape hand
Ape hand results from ____ nerve dysfunction
median
_____ ______ = rupture of avulsion of extensor tendon at its insertion into distal phalanx
mallet finger
Mallet finger causes _______ at DIP
flexion
Gamekeeper’s thumb = sprain / rupture of _____ of MCP at first digit leading to ______ instability
UCL; MEDIAL
______ = genetic disorder of purine metabolism
gout
Gout leads to increased serum _____ acid
uric (hyperuricemia)
Gout = acid forms ______ and deposits into joints; most affected joints in gout?
crystals; knee and great toe!
Rx for gout? (4 meds)
- NSAIDs
- Cox2 inhibitors
- corticosteroids
- ACTH
3 PT goals for pt w/ gout?
- injury prevention
- education
- fast intervention
_______ = release of enzymes + abnormal biomechanical forces leading to fibrillation and articular cartilage damage
OA!
2 results of fibrillation and articular cartilage damage?
- cartilage loss
2. increased bone turnover (osteophytes)
6 risk factors for OA?
- age
- F>M
- obesity
- physical inactivity
- injury
- joint stress
Name 5 most common OA sites
- spine
- hand
- knee
- hip
- foot
Osteophytes in facet joints of L spine = _______
stenosis
OA at PIP = ______ node; OA at DIP = _____
Bouchard; Heberden
_____ = most common affected joint in OA
Knee
3 common findings in pt w/ knee OA ?
- varus
- flexion contracture
- crepitus
4 S/S of hip OA?
- walks w/ trendelenberg
- groin pain
- osteophytes
- flexion deformities
Most common area affected by OA in foot ?
1st MT joint
OA in foot: osteophytes cause ____ _____ + rigidus, bunions
hallux valgus
4 main X ray findings of OA?
- joint space narrowing
- osteophytosis
- subchondral cysts
- subchondral sclerosis
4 questions to ask pts suspected of having OA?
- pain most days over the last month ?
- pain over the last year?
- worse with activity ?
- received with res?
3 tests indicative of knee OA?
- flexion contracture
- abnormal gait
- swipe tests / patellar tap test +ve
5 categories of Rx for OA?
- weight loss
- exercise
- protective aids
- medications
- electromodalities
1 lb weight loss = __ lb decrease in knee joint stress per step; aim is to decrease __% of body weight
4; 10
Exercise for pt w/ OA: __ min moderate aerobic training, __ minute bouts
30;10
Most common med for pts with OA?
acetominophen
______ type FAI = decreased / absent waist of the junction of femoral neck and head
CAM
CAM type FAI is common in what population ?
young men
____ type FAI = abnormal acetabulum provides excessive cover of femoral head
pincer
______ or deep acetabulum seen in pincer type FAI
retroverted
Pincer type FAI is common in what population ?
women 30-40 years old
Does spondyloarthritis have a rheumatoid factor ?
NO
5 characteristics of spondyloarthritis ?
- spine inflammation
- synovitis
- eye inflammation
- NO RF (seronegative)
- can be hereditary
Gene commonly found in pts with spondyloarthritis?
HLA-B27
Is psoriatic arthritis more common in males or females?
equally common!
4 characteristics of psoriatic arthritis ?
- chronic
- erosive
- inflammation
- affects digit joints + axial skeleton
2 types of psoriatic arthritis?
- dactylitis
2. enthesitis
Common sites of enthesitis in psoriatic arthritis ?
heels and back
5 meds for psoriatic arthritis ?
- acetaminophen
- NSAIDS
- DMARDs
- corticosteroids
- biological response modifiers
3 PT goals for pt w/ psoriatic arthritis ?
- joint protection strategies
- maintain joint mechanics
- endurance