Multiple Sclerosis Vignette

Question 1

Clinical Features of MS

Answer 1

Fatigue, walking impairment, spasticity, cognitive impairment, etc
Secondary to demyelinating lesions in random locations that may or may not cause symptoms
Relapsing and remitting phase before progressive degeneration
Likely autoimmune

Question 2

Demyelination effects

Answer 2

Reduced nerve conduction velocity. Higher brain activity needed to perform normal tasks, leads to fatigue

Question 3

Therapies

Answer 3

Re-myelination
K channel blockers (Dalfapridine): improve signal conduction
T-cell conversion to anti inflammatory over inflammatory
Reduction of B cells early in course
Sodium channel blockers

Question 4

Decreased Amplitude

Answer 4

Marks Neuronal Loss

Question 5

Delay in response

Answer 5

Marks myelin loss

Question 6

Myelin decreases……

Answer 6

Capacitance