Multiple sclerosis Flashcards
What is the speed of an action potential down an typical mylenated axon?
12m/s
What is the typical age range of onset for MS?
16-45yo
What is the timeline of MS development?
pre-clinical -> first demyeliniating event -> relpasing-remitting -> transitional -> secondary progressive
When is the window for early treatment of MS
during the first demyelinating event -> relapsing-remitting
What are some suspected triggers of MS?
infectious agents
genetic predisposition
environmental factors
What are syptoms during the pre-clinical stage of MS?
fatigue
What are symptoms of the 1 demyelinating event?
foot drops, objective neurodeficits
What are symptoms of the relapse-remitting phase of MS?
- functional loss for at least 24hrs
- Onset of symptom may or may not be perceived by patient
- ~1 event / 18 months
- with age recovery lessens
What occurs during progressive MS?
progressive neurodegeneration without recovery
What is the role of T and B cells in MS?
They become abnormaly activated:
- cross BBB
- look for myelin
- ATTACK
How can B-cells be a therapeutic target in MS?
in MS B-cells perpetuate CNS inflamation and damage by cytokine secreting role -> activate T cells
B-Cell depletion should stop this -> decrease inflammation, stop B-cell T cell cross talk -> slow progression
How is dalfamprimide used to treat MS patients?
improves walking speed
- blocks K+ channel -> enhances conduction in demyelinated axons
- does not modify disease
- contraindicated w/ h/o seizures, renal impairment
up to 25% improvement in walking trial tests
