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Endocrinology > Multiple Endocrine Neoplasia Syndromes > Flashcards

Multiple Endocrine Neoplasia Syndromes Flashcards

1
Q

List the types of MEN syndromes?

A

MEN 1

MEN 2a and 2b

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2
Q

What is MEN 1?

A

AD gene mutation located on chromosome 11 that leads to tumours of (3 Ps):
1. Pituitary tumour (10-20%): prolactinoma, GH secreting tumour, ACTH secreting, non-hormone secreting

  1. Pancreatic islet tumours (60-70%)
  2. Parathyroid (primary hyperparathyroidism - 90%)
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3
Q

What is MEN 2a?

A

Medullary carcinoma of thyroid (90%)
Phaeochromocytoma (40-50%)
Parathyroid hyperplasia (10-20%)

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4
Q

What is MEN 2b

A

MEN 2a plus:
Mucosal neuromas
Intestinal ganglioneuromas
Marfanoid habitus

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Endocrinology (9 decks)

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