multiple endocrine neoplasia (MEN) Flashcards
1
Q
what is multiple endocrine neoplasia
A
MEN is a rare genetic disorder
causes tumours or hyperplasia (overgrowth) in two or more endocrine glands, which can lead to excessive hormone production.
There are three types of MEN: MEN1, MEN2A, and MEN2B
2
Q
MEN1 is characterised by tumours in the
A
PPP
pituitary tumours- prolactinoma
pancreatic and duodenal tumours
parathyroid hyperplasia
3
Q
MEN2A is characterised by tumours in the
A
TAP
thyroid medullary carcinoma
adrenal- phaeochromocytoma
parathyroid hyperplasia
4
Q
MEN2B is characterised by tumours in the
A
TAPM
thyroid medullary cancer
adrenal- phaeochromocytoma
parathyroid- hyperplasia or adenoma
mucosal neuromas
5
Q
what mutation is in MEN1
A
MENIN
6
Q
what mutation is in MEN2
A
RET
7
Q
what type is more common
A
type 1
8
Q
what is more severe
A
type 1
